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However, existing therapeutic strategies cannot simultaneously achieve potent antibacterial action and temporal microenvironment modulation. Herein, a self\u2010evolving hyaluronan\/poly(aspartic acid) hydrogel dressing integrating in situ Ag\n                    <jats:sup>+<\/jats:sup>\n                    \u2010to\u2010Ag nanozyme conversion function and hydrolyzable Fe\n                    <jats:sub>3<\/jats:sub>\n                    N\/Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    nanoheterojunction (nHJ) is presented to meet the intricate requirements of consecutive healing stages. At infectious inflammatory stage, nHJ\u2010based self\u2010oxygenated photodynamic and photothermal effects synergize with Ag\n                    <jats:sup>+<\/jats:sup>\n                    to combat multidrug\u2010resistant biofilm\u2010forming bacteria. Subsequently, Ag nanozymes with superoxide dismutase\/catalase\u2010like activities continuously scavenge reactive oxygen species while generating oxygen, facilitating macrophage M1\u2010to\u2010M2 repolarization and ensuing inflammatory\u2010to\u2010proliferative phase transition. Accumulated ammonia enhances cell proliferation, migration and angiogenesis. The dressing demonstrates exceptional biocompatibility and bioactivity in accelerating\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010infected full\u2010thickness cutaneous wound healing in a diabetic rat model, as validated by hemostatic, broad\u2010spectrum antibacterial, antioxidative and immunomodulatory abilities, enhanced oxygenation and cell proliferation, and extensive collagen deposition, vascularization and re\u2010epithelialization. RNA\u2010seq results further reveal the activation of multiple pro\u2010healing signaling axes. Consequently, this platform offers a powerful dynamic strategy of realizing robust antibacterial activity and active temporal niche modulation to guide the healing of infected diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adma.202523302","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:32:17Z","timestamp":1776767537000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Self\u2010Evolving Hydrogel Dressing Temporally Accelerates Infected Diabetic Wound Healing"],"prefix":"10.1002","volume":"38","author":[{"given":"Chenyang","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology The First 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