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It is possible to develop targeted nanodrugs that selectively kill cancer cells via cuproptosis. However, the dense stroma of PDAC acts as an airtight wall, which not only limits the penetration and distribution of therapeutic agents but also promotes immunosuppressive mechanisms via its hypoxia\u2010promoting effects, often leading to treatment failure. Thus, we developed a near\u2010infrared (NIR)\u2010responsive semiconductor polymer\u2010metal\u2012organic framework (MOF) nanoreactor (SPNMCH) that was loaded with copper sulfide nanoclusters (CuS\n                    <jats:sub>x<\/jats:sub>\n                    NCs) and hyaluronidase (HAase). This biomimetic semiconductor \u201cbomb\u201d extensively demolishes the wall (by highly activating HAase) and precisely eliminates tumor cells (through its active copper uptake to induce cuproptosis). Simultaneously, the synergistic effects of increased oxygen delivery and cuproptosis elicit robust antitumor immune responses to inhibit tumor progression and distant metastasis, and strong immune memory effects as observed in four mouse cancer models. Additionally, SPNMCH can be combined with anti\u2010programmed death receptor 1 (PD\u20101) antibodies to further promote T cell\u2010mediated antitumor immunity. This study reveals a promising strategy for establishing a \u201chot\u201d tumor immune niche in PDAC to promote the response to immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.202523468","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T07:13:38Z","timestamp":1790579618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertemperature\u2010Detonated Biomimetic Semiconductor Stromal Bombs for Enhanced Immunotherapy in Pancreatic Cancer"],"prefix":"10.1002","author":[{"given":"Chengke","family":"Xie","sequence":"first","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital Fujian Provincial Hospital  Fuzhou China"},{"name":"Department of Hepatobiliary Pancreatic Surgery Fuzhou University Affiliated Provincial Hospital Fujian Provincial Hospital Fuzhou University  Fuzhou 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