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Calcium peroxide (CaO\n                    <jats:sub>2<\/jats:sub>\n                    )\u2010catalase\u2010based oxygen\u2010releasing biomaterials are a common solution, but the uncontrolled release of oxygen bubbles often leading to structural damages is rarely discussed. Herein, we present a strategy to control the site of bubble formation in an oxygen\u2010releasing hydrogel, by applying a catalase nanocoating to its surface. CaO\n                    <jats:sub>2<\/jats:sub>\n                    undergoes hydrolytic decomposition with water, generating hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), subsequently converts into O\n                    <jats:sub>2<\/jats:sub>\n                    and H\n                    <jats:sub>2<\/jats:sub>\n                    O. Because H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    can induce cytotoxicity, direct catalase incorporation into hydrogel systems may accelerate O\n                    <jats:sub>2<\/jats:sub>\n                    bubble formation, leading in hydrogel collapse within 1\u00a0h of aqueous immersion. In comparison, catalase\u2010coated hydrogels exhibited improved structural stability, showing a 5.9\u2010fold smaller bubble size than hydrogels with mixed catalase after 24\u00a0h in ambient air. Under hypoxic conditions (O\n                    <jats:sub>2<\/jats:sub>\n                    &lt; 0.1%), centimeter\u2010scale constructs containing catalase\u2010coated hydrogels preserved up to 86% viable human fibroblast cells after 5 days of culture, compared with only 47% in non\u2010catalase coated hydrogels. Furthermore, the incorporation of catalase\u2010coated hydrogels promoted cell survival and neurite outgrowth of human neural stem cells cultured in neuronal differentiation conditions under severe hypoxia. These findings suggest the potential of the proposed strategy for oxygen\u2010supportive tissue engineering applications.\n                  <\/jats:p>","DOI":"10.1002\/adma.202523593","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:27:34Z","timestamp":1781000854000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bubble Formation Control: Fabrication of Centimeter\u2010Sized Tissue\u2010Like Constructs by Catalase\u2010Coated Oxygen\u2010Releasing Hydrogel"],"prefix":"10.1002","volume":"38","author":[{"given":"Sukulya","family":"Bunuasunthon","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry Graduate School of Engineering The University of Osaka  Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel F.","family":"Amaral","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o 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