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In this study, a\n                    <jats:italic>Drosera capensis<\/jats:italic>\n                    \u2013inspired thermo\u2010responsive microneedle (MN) platform was developed, integrating motion, surface, and functional mimicry through AI\u2010guided 4D printing. Shape memory polymers (SMPs) composed of tert\u2010butyl acrylate (tBA) and 1,6\u2010hexanediol diacrylate (HDDA) were designed to exhibit reversible shape recovery upon thermal stimulation. The complex shape\u2010memory behavior was quantitatively modeled using multiple machine learning (ML) algorithms, including support vector regression (SVR), extreme gradient boosting (XGB), and Gaussian process regression (GPR). Among them, GPR demonstrated superior predictive accuracy (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0&gt;\u00a00.99) and provided predictive means and 95% confidence intervals, highlighting its reliability in modeling nonlinear thermal recovery behavior and its potential for guiding process parameter optimization. The resulting MNs exhibited\n                    <jats:italic>Drosera capensis<\/jats:italic>\n                    \u2010like coiling and grasping motions, enabling self\u2010actuating wound closure. Furthermore, the MNs were functionalized with adhesive DNA (aDNA) and Zn nanolayers via sputtering\u2010based plasma immersion ion implantation (S\u2010PIII). The Zn nanolayers facilitated sustained DNA release and endowed the MNs with intrinsic antibacterial activity. In diabetic wound models, the AI\u2010optimized biomimetic MN (BMMN) system significantly enhanced epithelial regeneration, collagen remodeling, and neovascularization, demonstrating adaptive and intelligent wound healing materials.\n                  <\/jats:p>","DOI":"10.1002\/adma.202523665","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T13:04:58Z","timestamp":1774875898000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["AI\u2013Guided 4D Printing of Carnivorous Plants\u2013Inspired Microneedles for Accelerated Wound Healing"],"prefix":"10.1002","volume":"38","author":[{"given":"Hyun","family":"Lee","sequence":"first","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon\u2010Jo","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongEung","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Ho","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Materials Science and Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seojoon","family":"Bang","sequence":"additional","affiliation":[{"name":"Division of Materials Science and Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong Seok","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Materials Science and Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Yeong","family":"Gwon","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hwa","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Materials Science and Engineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyub","family":"Jeon","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhyuk","family":"Son","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munwon","family":"Lim","sequence":"additional","affiliation":[{"name":"Research Institute of Intelligent Manufacturing &amp; Materials Technology Korea Institute of Industrial Technology  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minho","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Biotechnology The Catholic University of Korea  Bucheon Republic of Korea"},{"name":"Department of Biomedical\u2010Chemical Engineering The Catholic University of Korea  Bucheon Gyeonggi\u2010do Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Hoon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Doo","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Systems Biotechnology Chung\u2010Ang University  Anseong\u2010si Gyeonggi\u2010do Republic of 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