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To address this, we developed an injectable self\u2010assembling peptide hydrogel that encapsulates TAC within a microcrystalline phase via a novel multiphase assembly strategy. This hydrogel enables sustained TAC release, maintaining therapeutic blood concentrations (5\u201315 ng\/mL) for seven days post\u2010injection. In a vascularized composite allotransplant model, TAC\u2010loaded hydrogel preserves skin integrity on day 7 with vessel sutures, highlighting its potential for tissue preservation. In a life\u2010sustaining kidney transplantation model, rats receiving a single injection of TAC\u2010loaded hydrogel exhibited significantly improved survival (\u223c68 days) compared to the oral administration group (\u223c21 days). Histopathological and blood analysis confirmed minimal inflammation and intact tissue architecture in hydrogel\u2010treated grafts, alongside no systemic toxicity in major organs. These findings highlight multiphase assembly as a novel, effective strategy for controlled TAC release, offering a promising approach to improve patient outcomes in organ transplantation.<\/jats:p>","DOI":"10.1002\/adma.72590","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:24:39Z","timestamp":1772972679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Microcrystalline\u2010Infused Peptide Hydrogel Enables Sustained Tacrolimus Delivery to Prolong Survival and Prevent Rejection in Kidney Transplantation"],"prefix":"10.1002","volume":"38","author":[{"given":"Di","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Urology Xijing Hospital Fourth Military Medical University  Xi'an P. R. 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