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Herein, a strategy to design multifunctional self\u2011assembling peptides (NPR36) for preventing NIHL is presented. Compared to the conventional approach of constructing multifunctional self\u2010assembling peptide systems through co\u2010assembling distinct functional peptides, this strategy integrates multiple functions into a single self\u2010assembling peptide by conjugating multifunctional hormone\u2010derived peptides with extended basic self\u2010assembling peptides. This monolithic integration eliminates the need to balance concentration ratios and prevents efficacy loss that occurs when the concentration of any component drops below its therapeutic threshold, while also ensuring that each peptide possesses complete multifunctionality, thereby enhancing therapeutic effects. Benefiting from the non\u2010covalent interactions of the extended assembly motif, NPR36 self\u2011assembling peptides can form nanofibers and achieve sustained release during disassembly, maintaining an effective concentration at the treatment site. Furthermore, a fiber\u2010microalgae complex was formed by combining NPR36 with Spirulina platensis. This fiber\u2010microalgae\u2010based system synergistically exerted antioxidant and anti\u2010apoptotic effects, markedly reducing hair cell loss and restoring hearing. Overall, preventive interventions based on multifunctional self\u2010assembling peptides could overcome the clinical translation challenges in the prevention of inner ear disorders.<\/jats:p>","DOI":"10.1002\/adma.72706","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:02:41Z","timestamp":1772989361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multifunctional Self\u2010Assembling Peptide System for Preventing Noise\u2010Induced Hearing Loss"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1693-4680","authenticated-orcid":false,"given":"Jiawen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Zhongnan Hospital of Wuhan University  Wuhan 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