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Yet, the mechanical\u2010immunological mismatch between rigid electrodes and soft tissues continues to limit long\u2010term device stability. Here, we present SSPH, an immunocompatible, injectable, conductive hydrogel bridge that enables minimally invasive delivery and stable tissue integration. By forming a compliant interfacial bridge, SSPH reduces mechanical\u2010biological mismatch and immune stress on electrodes. It is formed by the spontaneous co\u2010assembly of PEDOT:PSS and the zwitterionic polymer poly(sulfobetaine methacrylate) (PSBMA), resulting in a 3D network stabilized by anion\u2010\u03c0 interactions, electrostatic interactions, and PEDOT\u2010rich nanostructures. This self\u2010healable architecture allows SSPH to maintain its intrinsic conductive pathways after deformation. Experiments confirmed that SSPH exhibits stable electrochemical properties and favorable immunocompatibility. In an acute muscle injury model, SSPH restored signal transmission across the damaged region, demonstrating its potential to serve as a bridge across disrupted tissue. Furthermore, in both electromyography recording and spinal cord stimulation models, SSPH preserved electrode performance for up to four weeks, supporting reliable bidirectional signal conduction. These results highlight SSPH as a promising, durable, and immunocompatible bridging material for sustained bioelectronic interfaces.<\/jats:p>","DOI":"10.1002\/adma.72820","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:40:21Z","timestamp":1773844821000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["An Immunocompatible Conductive Hydrogel Via Anion\u2010\u03c0 Interlocking as an Injectable Bridge for Sustained Bioelectronic Interfacing"],"prefix":"10.1002","volume":"38","author":[{"given":"Zihao","family":"Zhu","sequence":"first","affiliation":[{"name":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University  Hangzhou Zhejiang Province P. R. 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