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To overcome this, we develop a FeMn dual\u2010atom nanozyme supported on oxygen\u2010nitrogen\u2010doped bamboo\u2010like carbon nanotubes (FeMn\n                    <jats:sub>DA<\/jats:sub>\n                    \/BCNT). Through the precise alignment of Fe and Mn 3\n                    <jats:italic>\n                      dz\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:italic>\n                    orbital energy levels by the electron\u2010delocalized BCNT support in the FeMn\u2010N\/O active center, thereby lowering the dissociation energy barrier for\n                    <jats:sup>*<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    or\n                    <jats:sup>*<\/jats:sup>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    O molecules, promoting O\u2500O bond cleavage to bypass toxic \u2500OOH species, and thus accelerating the enzyme\u2010like kinetics. Combined with a hierarchical porous bamboo\u2010like structure of the BCNT that enhances high specific surface, atom exposure, and mass transfer, the FeMn\n                    <jats:sub>DA<\/jats:sub>\n                    \/BCNT nanozymes exhibit potent superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)\u2010like activities. Further encapsulation with a macrophage membrane ([MM]FeMn\n                    <jats:sub>DA<\/jats:sub>\n                    \/BCNT) confers excellent biocompatibility and active targeting ability toward inflammatory sites. The resulting [MM]FeMn\n                    <jats:sub>DA<\/jats:sub>\n                    \/BCNT nanozymes target the inflammatory microenvironment, scavenges ROS, restores mitochondrial function, and suppresses NLRP3 inflammasome activation, thereby inhibiting pyroptosis. In vivo, [MM]FeMn\n                    <jats:sub>DA<\/jats:sub>\n                    \/BCNT nanozymes show good biocompatibility and efficacy in treating osteoarthritis, acute liver injury, and acute kidney injury. This work provides a novel strategy for inflammatory disease therapy using a biomimetic dual\u2010atom nanozyme.\n                  <\/jats:p>","DOI":"10.1002\/adma.72857","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:09:34Z","timestamp":1774501774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reengineering Aligned D\u2010Orbital Energy Levels in FeMn Dual\u2010Atom Nanozyme Inhibits Pyroptosis for Effective Alleviation of Inflammatory Diseases"],"prefix":"10.1002","volume":"38","author":[{"given":"Jianfeng","family":"Guo","sequence":"first","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Coconstructed By the Province and Ministry Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi P. R. China"},{"name":"Department of Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Coconstructed By the Province and Ministry Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The Ninth Affiliated Hospital of Guangxi Medical University  Beihai Guangxi P. R. 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