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To address these challenges, we developed a G\u2010quadruplex (G4)\u2010modular CpG nanoplatform named IONP\u2010G4\u2010DOX\/IMT, which uses iron oxide nanoparticles (IONPs) as a stable structural and biocompatible core and G4 as a multifunctional hub. The rationally designed G4 module enables three synergistic functions encompassing enhanced CpG nuclease resistance for sustained TLR9 pathway activation, site\u2010specific loading of doxorubicin (DOX) to trigger potent immunogenic cell death (ICD) and release tumor antigens, and IMT anchoring to activate the cGAS\u2010STING pathway. These three processes are structurally coordinated and functionally synergistic, collectively driving robust dendritic cell maturation, boosting CD4\n                    <jats:sup>+<\/jats:sup>\n                    \/CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration, and reducing regulatory T cell accumulation. This cascade of immune modulation effectively reprograms the TME into an immune\u2010permissive state. In murine 4T1 breast cancer models, IONP\u2010G4\u2010DOX\/IMT achieves a primary tumor suppression rate of approximately 79.4%, with no significant systemic toxicity. More importantly, it elicits potent long\u2010term antitumor immunity that inhibits contralateral tumor growth, offering a versatile and promising strategy for advanced abscopal chemoimmunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.72908","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:16:39Z","timestamp":1774444599000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["G\u2010Quadruplex\u2010Modular CpG Nanoplatform Drives Multi\u2010Pathway Immunity for Abscopal Chemoimmunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Mengxue","family":"Sun","sequence":"first","affiliation":[{"name":"Beijing National Laboratory for Molecular Sciences (BNLMS) State Key Laboratory For Structural Chemistry of Unstable and Stable Species Institute of Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"University of the Chinese Academy of Sciences (UCAS)  Beijing China"},{"name":"Guangzhou Wondfo Biotech Co. 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