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However, conventional implants suffer from non\u2010adaptive nerve interfaces, including geometric mismatch, suture\u2010related trauma, and absence of neuron\u2010like bioelectrical signals, which significantly undermine their long\u2010term biosafety and efficacy. Here we present a multifunctional ferroelectric bioelectronic interface (FBI) that integrates a bilayer natural polymer\u2010based hydrogel, ferroelectric poly(vinylidene fluoride\u2010\n                    <jats:italic>co<\/jats:italic>\n                    \u2010trifluoro ethylene) (P(VDF\u2010TrFE)) polymer, and photothermal carbon nanotubes (CNT), imparting unprecedented synergistic functions, including self\u2010rolling geometric matching, strong interfacial adhesion that eliminates the need for suturing, and neuron\u2010mimetic polarization\u2010change\u2010induced bioelectrical signaling. When applied to the vagus nerves, this adaptive FBI enables near\u2010infrared\u2010mediated neuromodulation that effectively reduces pro\u2010inflammatory cytokine levels. Compared with conventional vagus nerve modulators, such innovative FBI avoids nerve compression, minimizes focal inflammation, and maintains persistent neuromodulation efficacy during long\u2010term implantation. By integrating precise geometric adaptability, seamless bioadhesive fixation, bioelectrical biomimicry, and robust biosafety, the FBI platform offers a new paradigm for next\u2011generation implantable bioelectronics for durable nerve modulation and treatment of neurological and autoimmune conditions.\n                  <\/jats:p>","DOI":"10.1002\/adma.73023","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:30:04Z","timestamp":1775734204000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multifunctional Ferroelectric Bioelectronic Interfaces for Long\u2010Term Biosafe Vagus Nerve Modulation"],"prefix":"10.1002","volume":"38","author":[{"given":"Xule","family":"Zhu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biomedical Imaging Science and System Center For Intelligent Biomedical Materials and Devices (IBMD) Shenzhen Institutes of Advanced Technology (SIAT) Chinese Academy of Sciences (CAS)  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomedical Imaging Science and System Center For Intelligent Biomedical Materials and Devices (IBMD) Shenzhen Institutes of Advanced Technology (SIAT) Chinese Academy of Sciences (CAS)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences Key Laboratory for Neuroscience PKU\u2010IDG\/McGovern Institute for Brain Research Ministry of Education\/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-5759","authenticated-orcid":false,"given":"Xuemin","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomedical Imaging Science and System Center For Intelligent Biomedical Materials and Devices (IBMD) Shenzhen Institutes of Advanced Technology (SIAT) Chinese Academy of Sciences (CAS)  Shenzhen China"},{"name":"University of Chinese Academy of Sciences  Beijing 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