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Herein, we report an all\u2010in\u2010one hydrogel design based on a highly biocompatible, covalently interlinked, and multifunctional carbon dot (CD) platform for simultaneous regulation of antibacterial, anti\u2010inflammatory, and osteogenic activities while enabling bacteria\u2010specific and controllable release of CDs. To achieve this aim, CDs was significantly modified with two structural factors, i.e., catechol grafted at the edge and Se\u2500Se bonds doped in the core, which play crucial roles in the precise regulation of their multiple functions for on\u2010demand osteomyelitis therapy. Dynamically crosslinked composite hydrogels with dissociable borate ester bonds were constructed by utilizing catechol\u2010functionalized Se\u2010doped CDs as a triple bioactive ingredient. The CD\u2010based composite hydrogels were demonstrated to enable near\u2010complete healing of bone defects in a MRSA\u2010induced osteomyelitis model. This work provides a paradigm for fabrication of dynamic\u2010crosslinked hydrogels from multifunctional CDs for on\u2010demand osteomyelitis therapy.<\/jats:p>","DOI":"10.1002\/adma.73080","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:56:38Z","timestamp":1776509798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dynamically Crosslinked Carbon Dot\/Alginate Hydrogels for On\u2010Demand Osteomyelitis Therapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7491-8055","authenticated-orcid":false,"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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