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Integrating sequencing of patient\u2010derived organoids with resistant models, we identified a metabolic rewiring characterized by GPX4 upregulation and concomitant ACSL4 suppression as the driver of a ferroptosis\u2010evading phenotype. Uniquely, we harness the resistance\u2010driving electric field itself as a wireless energy source to fuel a material\u2010based chemical attack against this antioxidant defense. To breach this barrier, we developed Ba\n                    <jats:sub>2<\/jats:sub>\n                    FeNbO\n                    <jats:sub>6<\/jats:sub>\n                    (BFNO), a defect\u2010rich double\u2010perovskite acting as a wireless electro\u2010Fenton catalyst. Under TEFT, BFNO harvests electric energy to accelerate Fe\u2010ion redox cycling, precipitating a catastrophic ROS storm that overwhelms antioxidant defenses and triggers hybrid lysosomal ferroptosis and GSDME\u2010mediated pyroptosis. This process culminates in immunogenic cell death, resensitizing refractory tumors. Furthermore, combining BFNO with PD\u20101 blockade effectively reverses adaptive immune resistance and T\u2010cell exhaustion, reshaping the immunosuppressive microenvironment. Our study establishes a strategy to repurpose the electric field into a lethal biochemical trigger, overcoming resistance and potentiating immunotherapy in glioblastoma.\n                  <\/jats:p>","DOI":"10.1002\/adma.73126","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T10:45:04Z","timestamp":1776509104000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Wireless Electro\u2010Fenton Overcomes Tumor Electric Field Treatment Resistance"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-9330","authenticated-orcid":false,"given":"Boyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Cheeloo College of Medicine and Institute of Brain and Brain\u2010Inspired Science Qilu Hospital Shandong University Jinan Shandong P. R. 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