{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:44:01Z","timestamp":1789587841027,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"31","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22505132"],"award-info":[{"award-number":["22505132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MB008"],"award-info":[{"award-number":["ZR2022MB008"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023QB077"],"award-info":[{"award-number":["ZR2023QB077"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","award":["sqn201812072"],"award-info":[{"award-number":["sqn201812072"]}],"id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Crystalline organic nanomaterials with programmable photophysical functions hold great promise for precision medicine, however, achieving controlled crystallization and responsive activation remains challenging. Here we report a kinetically gated and self\u2010limiting crystallization (KGSLC) strategy for constructing allosteric phototheranostic nanocrystals. Through rational molecular design, the TCF acceptor unit governs intrinsic size confinement via surface hydration, while the hydroxyl group directs hydrogen\u2010bond\u2010assisted\n                    <jats:italic>\u03c0<\/jats:italic>\n                    \u2013\n                    <jats:italic>\u03c0<\/jats:italic>\n                    stacking to promote highly crystalline assemblies. The resulting HICyT nanocrystals (HICyT NCs) exhibit strong near\u2010infrared absorption, dual\u2010type reactive oxygen species generation, and catalase\u2010like activity. A disulfide\u2010bridged prodrug, (HICyT)\n                    <jats:sub>2<\/jats:sub>\n                    S, further encodes tumor microenvironment\u2010triggered activation, converting into active HICyT NCs upon glutathione cleavage. The resulting nanocrystals enable deep\u2010tissue penetration, bright albumin\u2010activated NIR\u2010I\/II fluorescence, and potent in vivo tumor ablation under irradiation. This kinetically programmed crystallization integrates structural precision, spatiotemporal activation, and real\u2010time imaging into a single organic platform, offering a promising route toward self\u2010reporting phototheranostic materials.\n                  <\/jats:p>","DOI":"10.1002\/adma.73232","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:14:01Z","timestamp":1777450441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kinetically Gated and Self\u2010Limiting Crystallization Enables Allosteric Phototheranostic Nanocrystals"],"prefix":"10.1002","volume":"38","author":[{"given":"Xueluer","family":"Mu","sequence":"first","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-7486","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangjie","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbi","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Material Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1873-6510","authenticated-orcid":false,"given":"Dan","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology Nankai University  Tianjin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-3180","authenticated-orcid":false,"given":"Xianfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"},{"name":"College of Material Science and Engineering Qingdao University of Science and Technology  Qingdao P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4542"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010020\u20100410\u20102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000892\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002140\u2010y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/113080a0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001242\u2010w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/064301d0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010016\u20100010"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2986"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2009.231"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.343"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010021\u201000328\u20106"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c09462"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c04111"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202111767"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CS00671H"},{"key":"e_1_2_9_18_1","first-page":"540","volume-title":"Exploring and Leveraging Aggregation Effects on Reactive Oxygen Species Generation in Photodynamic Therapy","author":"Zhuang Z.","year":"2024"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.215863"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305163"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c01645"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmaterialslett.2c00972"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200374"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpclett.9b01040"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar900233v"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010024\u201000990\u20104"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106568"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201803325"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904799"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139760"},{"key":"e_1_2_9_31_1","first-page":"170","volume-title":"Boost Photothermal Theranostics via Self\u2010Assembly\u2010Induced Crystallization (SAIC)","author":"Mu X.","year":"2022"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201906711"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.6b00576"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1667\/RRAV03.1"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.07.032"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja513034e"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202101460"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.73232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.73232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.73232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:15:01Z","timestamp":1782976501000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.73232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":36,"journal-issue":{"issue":"31","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/adma.73232"],"URL":"https:\/\/doi.org\/10.1002\/adma.73232","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"2025-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73232"}}