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Injectable hydrogels with robust multi\u2010bond crosslinked networks, integrating fluidity and in situ stability, are promising for efficient hemostasis, but their crosslinkers\u2019 relatively single structures limit the multifunctionality required for effective trauma management in resource\u2010scarce environments. Herein, a new class of versatile \u03b5\u2010polylysine grafted manganese dioxide (EPL\u2010\n                    <jats:italic>g<\/jats:italic>\n                    \u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    ) nano\u2010crosslinkers is synthesized to construct an injectable hydrogel (i.e., OSEG hydrogel). Driven by EPL\u2010\n                    <jats:italic>g<\/jats:italic>\n                    \u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    , OSEG hydrogel rapidly achieves stable wet adhesion and efficient hemostasis in critical injuries (e.g., 24.9 s in a rabbit model of cardiac hemorrhage) via imine, hydrogen, and ionic bonds, which form a robust and multifunctional crosslinked network upon full gelation.\u00a0In the microenvironment of traumatic wounds, OSEG hydrogel undergoes accelerated degradation to further expose EPL\u2010\n                    <jats:italic>g<\/jats:italic>\n                    \u2010MnO\n                    <jats:sub>2<\/jats:sub>\n                    and spermidine, thereby providing sufficient antibacterial and pro\u2010healing effects. As a result, OSEG hydrogel achieves a bone volume\/total volume 3.3 times that of commercial hemostat SURGIFLO in a rat model of infected cranial defect. This work may inspire the design of advanced injectable hydrogels for synergistic trauma management.\n                  <\/jats:p>","DOI":"10.1002\/adma.73277","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:34:28Z","timestamp":1779111268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Versatile Nano\u2010Crosslinker Enhanced Injectable Hydrogel Toward Rapid Hemostasis and Efficient Trauma Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiaoshuai","family":"Peng","sequence":"first","affiliation":[{"name":"Guangdong Provincial Clinical Research Center for Orthopedic Diseases The Eighth Affiliated Hospital Sun Yat\u2010sen University  Shenzhen P. R. 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