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However, existing microbes suffer from inadequate near\u2010infrared (NIR) responsiveness and photoelectron injection. Here, we engineer a microbial\u2010semiconductor hybrid by electrostatically assembling copper sulfide\u2010loaded layered double hydroxide (LDH\/CuS) nanosheets onto the surface of\n                    <jats:italic>Rhodopseudomonas palustris<\/jats:italic>\n                    (\n                    <jats:italic>R.P<\/jats:italic>\n                    .) for NIR\u2010driven photosynthetic H\n                    <jats:sub>2<\/jats:sub>\n                    immunotherapy. The LDH\/CuS enhances NIR capture and forms a p\u2012n heterojunction that weakens the electron exclusion barrier, enabling directed pumping of photogenerated electrons into\n                    <jats:italic>R.P<\/jats:italic>\n                    . Under 808\u00a0nm irradiation, the LDH\/CuS heterojunction boosts photoelectron injection into the hydrogenase system of\n                    <jats:italic>R.P<\/jats:italic>\n                    . by 6.8\u2010fold, achieving highly efficient photosynthetic H\n                    <jats:sub>2<\/jats:sub>\n                    production. Notably, the\n                    <jats:italic>R.P<\/jats:italic>\n                    .@LDH\/CuS actively colonizes hypoxic tumors with a high targeting efficiency of 73.2% and selectively converts tumor\u2010enriched lactic acid (LA) and glycogen into H\n                    <jats:sub>2<\/jats:sub>\n                    under NIR stimulation. Through the LA depletion and immunogenic cell death induction, the microbial\u2010semiconductor hybrid triggers potent antitumor immune responses, increasing infiltrated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells by over 9\u2010fold and achieving a remarkable tumor inhibition rate of 97.8%. This work presents an NIR\u2010driven biohybrid system with spatially directional electron pumping for efficient photosynthetic H\n                    <jats:sub>2<\/jats:sub>\n                    generation, advancing a promising paradigm for precision\u2010targeted tumor immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.73476","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:11:21Z","timestamp":1779693081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microbial\u2010Semiconductor Hybrids Enable Near Infrared\u2010Driven Photosynthetic Hydrogen Production for Tumor\u2010Targeted Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Ruimin","family":"Xue","sequence":"first","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology  Beijing P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanning","family":"Jin","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology  Beijing P. R. 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