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Herein, a one\u2010step amyloid\u2010mediated surface modification method is proposed to encapsulate HPMs by immersing them in a phase\u2010transitioned bovine serum albumin (PTB) aqueous solution. The resultant amyloid\u2010like PTB nanocoating modified activated carbon exhibited a nearly four\u2010fold increase in the adsorption capacity for urea and creatinine, as well as significantly enhanced adsorption toward other harmful substances, including heavy metal chromium ion, drug norfloxacin, medium\u2010molecule toxin bilirubin, and large\u2010molecule toxin interleukin\u20106. Additionally, the hemocompatibility of activated carbon is substantially improved by reducing carbon debris formation, minimizing damage to blood cells, and effectively alleviating non\u2010specific adsorption of plasma proteins while resisting platelet adhesion. The superior blood purification performance was validated in vivo using multiple animal models of chronic kidney disease. Notably, this strategy is broadly applicable to various HPMs, such as polymeric resins and emerging materials such as carbon nanotubes and metal\u2010organic frameworks, offering an effective and highly general surface engineering approach to enhance the performance of various blood purification materials with significant clinical implications.<\/jats:p>","DOI":"10.1002\/adma.73480","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:52:21Z","timestamp":1779695541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Amyloid\u2010Like Nanocoatings for Enhanced Hemoperfusion Materials"],"prefix":"10.1002","volume":"38","author":[{"given":"Xingyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Applied Surface and Colloid Chemistry School of Chemistry and Chemical Engineering Ministry of Education Shaanxi Normal University  Xi'an 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