{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:45:05Z","timestamp":1791827105956,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201002303658"],"award-info":[{"award-number":["RS\u20102025\u201002303658"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000420452"],"award-info":[{"award-number":["RS\u20102024\u201000420452"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Biological tissues exhibit nonlinear strain\u2010stiffening behavior with distinct toe (\n                    <jats:italic>\n                      E\n                      <jats:sub>Toe<\/jats:sub>\n                    <\/jats:italic>\n                    ) and heel (\n                    <jats:italic>\n                      E\n                      <jats:sub>Heel<\/jats:sub>\n                    <\/jats:italic>\n                    ) moduli essential for load\u2010bearing function. However, synthetic materials lack a unified strategy and mechanistic basis for independently tuning\n                    <jats:italic>\n                      E\n                      <jats:sub>Toe<\/jats:sub>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      E\n                      <jats:sub>Heel<\/jats:sub>\n                    <\/jats:italic>\n                    while maintaining high\u2010fidelity 3D printability. Here, we introduce a 3D\u2010printable strain\u2010stiffening double\u2010network granular hydrogel (SDGH) that enables region\u2010specific control of\n                    <jats:italic>\n                      E\n                      <jats:sub>Toe<\/jats:sub>\n                    <\/jats:italic>\n                    and\n                    <jats:italic>\n                      E\n                      <jats:sub>Heel<\/jats:sub>\n                    <\/jats:italic>\n                    through modulation of secondary\u2010network monomer concentration and microgel packing density, respectively. We elucidate the mechanism of strain\u2010stiffening behavior using in situ microscopic imaging and mechanical analysis. To demonstrate utility, we direct\u2010ink\u2010write multilayered aortic valves using alternating soft and stiff inks. The printed valves, selected for their demanding mechanical and heterogeneous architecture, showed high geometric fidelity and excellent hemodynamic performance, achieving regurgitation &lt;1.2% and surpassing ISO 5840 standards. This platform establishes a generalizable design framework for customized tissue mimetic organs for biomedical applications, particularly in synthetic surgical training material.\n                  <\/jats:p>","DOI":"10.1002\/adma.73527","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T12:21:43Z","timestamp":1780316503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineering Strain\u2010Stiffening Granular Hydrogels for 3D\u2010Printed Tissue\u2010Mimicry"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5595-9294","authenticated-orcid":false,"given":"Hyeokju","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of 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