{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:32:36Z","timestamp":1787758356161,"version":"build-2784847793"},"reference-count":56,"publisher":"Wiley","issue":"41","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271031"],"award-info":[{"award-number":["82271031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571158"],"award-info":[{"award-number":["82571158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011636"],"award-info":[{"award-number":["2024A1515011636"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010833"],"award-info":[{"award-number":["2024A1515010833"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The exposed and microbe\u2010rich microenvironment requires the soft tissue regeneration materials to balance conflicting characteristics, including biodegradation, mechanical stability, and biological activity. Herein, this research engineers a glycoprotein\u2010inspired soft tissue regeneration membrane by precisely grafting the diblock copolymer from a robust fish swim bladder collagen matrix via surface\u2010initiated reversible addition\u2010fragmentation chain transfer polymerization. Benefitting from the naturally dense fibrous network and in situ crosslinking, the modified collagen membrane maintains structural integrity and mechanical support prior to tissue maturation, followed by progressive degradation to facilitate new tissue replacement. More importantly, the grafted diblock copolymer orchestrates a spatiotemporal synchronized defense and pro\u2010healing efficacy. It not only maintains microbial homeostasis while constructing a hydration\u2010based exclusion barrier against pathogenic biofilms, but also activates integrin\u2010mediated cell adhesion and various regeneration\u2010related behaviors. Consequently, this sophisticated design harmonizes degradation kinetics and anti\u2010biofilm efficacy with the spatiotemporal demands of healing. As a result, the diblock copolymer engineered swim bladder membrane transcends passive scaffolding, offering comprehensive and active protection and promotion for challenging soft tissue regeneration.<\/jats:p>","DOI":"10.1002\/adma.73547","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:13:38Z","timestamp":1783329218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diblock Copolymer Engineered Swim Bladder Membrane Enables Spatiotemporal Synchronized Defense and Pro\u2010Healing in Challenging Soft Tissue Regeneration"],"prefix":"10.1002","volume":"38","author":[{"given":"Shulu","family":"Luo","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongheng","family":"Cen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhike","family":"Huang","sequence":"additional","affiliation":[{"name":"Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-0097","authenticated-orcid":false,"given":"Dingcai","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, School of Chemistry Sun Yat\u2010sen University  Guangzhou P. R. China"},{"name":"Institute for Frontier Interdisciplinary Research in Health Sciences and Technology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-9397","authenticated-orcid":false,"given":"Shuyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology Sun Yat\u2010sen University  Guangzhou P. R. China"},{"name":"Institute for Frontier Interdisciplinary Research in Health Sciences and Technology Sun Yat\u2010sen University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010024\u201001035\u2010z"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.036"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.70010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201058062\u20104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbaf117"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043476\u20109"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202105348"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043428\u20103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162633"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.06.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043827\u20106"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138899"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.70019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305633"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413\u2010025\u201000471\u20108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.05.013"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000294\u2010x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102273"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002449\u2010w"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05682"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412407"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.2c00783"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c01018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjbiofilms.2015.22"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2021.05.028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14216447"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02321"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.03.036"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201707107"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4bm01132e"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.110019"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212302"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201060858\u20103"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168339"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202310079"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cis.2018.10.005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579\u2010022\u201000767\u20100"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12546"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202506113"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.261138"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000531\u20105"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2024.11.007"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41536\u2010021\u201000153\u2010z"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2024.01.023"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000716\u20100"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdev.2025.204053"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010024\u201000715\u20101"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010024\u201001125\u2010w"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20106147(00)01676\u2010x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001259\u20106"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2021.112731"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304537"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dtrs.2026.100032"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.73547","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.73547","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.73547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:11:06Z","timestamp":1787757066000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.73547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":56,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/adma.73547"],"URL":"https:\/\/doi.org\/10.1002\/adma.73547","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73547"}}