{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T09:07:35Z","timestamp":1783847255314,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"38","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Protecting cell\/tissue disservice during acute kidney injury (AKI) was an important but still challenging goal. Here, we proposed a current\u2010ultrasound convertion\u2010propelled wireless positioning and tracking nanomachine in which Au covered one side of a PASP\u2010PArg\/BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    footplate (Au@PASP\u2010PArg\/BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    , ASPB). These navigational nanomaches were used in the treatment of AKI to confirm a new technology and method for actively inhibiting kidney\u2010trauma formation to enable highly efficient kidney\u2010protection. ASPB possessed the high dielectric constant and piezoelectric properties, which acquired endogenous ultrasound\u2010current and guided navigation under exogenous current excitement. Under the triggering of endogenous ultrasound, ASPB further gave rise to the unbalanced charges on its surface and underwent oxidation\u2010reduction reactions with surrounding water, obtaining H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ; meanwhile, ASPB could also decompose water to produce O\n                    <jats:sub>2<\/jats:sub>\n                    under the inducement of endogenous ultrasound. Additionally, the attained H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and\n                    <jats:sup>1<\/jats:sup>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    catalyzed polyarginine to discharge NO. Importantly, under accurate navigation, endogenous ultrasound\u2010triggered gas sensor discharged NO\/O\n                    <jats:sub>2,<\/jats:sub>\n                    and endogenous current could protect renal tissues from damage based on modulating MYDGF expressions, KCNQ1 functions, and TMAO targeted metabolomics. These current\u2010ultrasound convertion\u2010pushed navigational nanomaches clearly unveiled illustrious potential for promoting highly efficient kidney\u2010function protection.\n                  <\/jats:p>","DOI":"10.1002\/adma.73566","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:37:13Z","timestamp":1780486633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanomachines Based on Inner Ultrasonic Multiple Scattering for Ameliorating Renal Function"],"prefix":"10.1002","volume":"38","author":[{"given":"Rui","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Binzhou Medical University  Yantai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Binzhou Medical University Hospital  Binzhou Shandong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6600-9778","authenticated-orcid":false,"given":"Fei","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Binzhou Medical University  Yantai P. R. 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