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However, the consequent perturbation of electron transfer states (e.g., flux overload or blockade) leads to electron accumulation, which enhances reactive oxygen species (ROS) generation. High ROS concentrations kill bacteria, while sublethal levels induce DNA damage, thereby elevating antibiotic resistance risk. In this study, we found that shunting electrons at critical ETC nodes is able to disrupt bacterial energy metabolism, damaging bacteria without ROS generation. To leverage the ROS\u2010free mechanism for infection control, we synthesized 5\u2010aminotetrazole\u2010functionalized gold nanocomplexes (ATZ\u2010Au) that intercept electron transfer from electron donors to downstream carriers. This rapidly depletes reduced nicotinamide adenine dinucleotide (NADH), disrupts the proton motive force (PMF), impairs ATP synthesis, and blocks bacterial compensatory metabolic pathways, ultimately leading to lethal intracellular acidosis and metabolic collapse. This effect blocks the capture of electrons by oxygen, thereby preventing the generation of ROS. The ATZ\u2010Au efficiently eliminates pathogenic bacteria in complex infections, providing a promising strategy to address antibiotic resistance.<\/jats:p>","DOI":"10.1002\/adma.73611","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:28:52Z","timestamp":1780579732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aminotetrazole\u2013Gold Nanocomplexes Shunt Electrons to Eradicate Bacteria Without ROS\u2010Induced Resistance"],"prefix":"10.1002","volume":"38","author":[{"given":"Mingzhi","family":"Huang","sequence":"first","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou 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