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However, they are typically constrained by static hardware architectures that limit adaptability and computational richness. Here, we introduce a reconfigurable microfluidic platform where soft hydrogel structures are 3D\u2010printed and erased in situ to dynamically reshape the physical environment in which chemical computation occurs. By treating microfluidic geometry as an active, programmable element rather than a passive container, we demonstrate hardware\u2010reconfigurable control over chemical information processing. We demonstrate switchable Deoxyribonucleic acid (DNA) logic gates that alternate between AND and OR functionality without modifying the underlying reaction network, decoupling logic function from molecular composition. Extending this to a non\u2010equilibrium chemical reaction network in the form of a feedback\u2010controlled pH oscillator, we demonstrate that printed structures steer reaction kinetics and spatial pattern formation, giving rise to geometry\u2010dependent spatiotemporal states. Leveraging these dynamics, we implement a physical reservoir computer in which reconfigurable microfluidic hardware enables the realization of diverse nonlinear functions through simple linear readout. Our work establishes reconfigurable soft microfluidic hardware as a control layer for chemical computation, highlighting how adaptable physical environments actively expand the computational state space of chemical software.<\/jats:p>","DOI":"10.1002\/adma.73669","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:18:16Z","timestamp":1781158696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Soft Hardware, Flowing Software: Reconfigurable Microfluidics for Adaptable Chemical Computation"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6118-9746","authenticated-orcid":false,"given":"Piet J. 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0188-6416","authenticated-orcid":false,"given":"Kohei","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Life\u2010Like Materials and Systems Department of Chemistry University of Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2170-3306","authenticated-orcid":false,"given":"Andreas","family":"Walther","sequence":"additional","affiliation":[{"name":"Life\u2010Like Materials and Systems Department of Chemistry University of Mainz  Mainz 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