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To break this cycle, we engineered a photothermal nanoplatform (CHPB@H) consisting of curcumin\u2010loaded hollow Prussian blue (CHPB) nanoparticles\u00a0embedded in an injectable thermosensitive chitosan hydrogel for near\u2010infrared (NIR)\u2010triggered local delivery. Upon NIR irradiation, the platform releases iron ions and curcumin that self\u2010assemble into Fe\u2010curcumin (Fe\u2010Cur) complexes. These complexes act as a molecular \u201cTrojan horse\u201d that hijacks bacterial iron\u2010acquisition pathways to induce ferroptosis. Concurrently, CHPB scavenges reactive oxygen species (ROS) via its intrinsic nanozyme activity and suppresses oxidative stress\u2010driven fibroblast activation, thereby dismantling the fibrotic barrier that excludes immune effector cells. This dual action eliminates biofilms and restores immune cell infiltration into the infection site. In preclinical animal models, the therapy clears established implant infections, remodels the immune\u2010fibrotic microenvironment, and promotes tissue regeneration. This work establishes a \u201cclear\u2010and\u2010remodel\u201d paradigm that integrates active targeted ferroptosis (via iron hijacking) with immuno\u2010fibrotic remodeling, offering a translatable strategy for complex implant\u2010associated biofilm infections.<\/jats:p>","DOI":"10.1002\/adma.73711","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T13:53:05Z","timestamp":1781358785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron\u2010Hijacking Trojan Horse Nanoplatform Combats Implant\u2010Associated Biofilm Infections Through Immuno\u2010Fibrotic Remodeling"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4591-3742","authenticated-orcid":false,"given":"Dongdong","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Zhengzhou University  Zhengzhou 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