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Reinstating wound bioelectricity therefore represents an attractive therapeutic strategy, and thermoelectric materials are particularly suited to this purpose by harvesting the natural skin\u2013air temperature gradient without external power input. Here, a self\u2010powered ionic thermoelectric dual\u2010network hydrogel is developed to simultaneously reconstruct wound bioelectric cues and remodel the hostile DFU microenvironment. The hydrogel generates wound\u2010relevant microcurrents under physiological temperature gradients, while luteolin and Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    are incorporated as complementary bioactive modules to suppress bacterial burden and excessive inflammation, thereby establishing a pro\u2010regenerative niche. Meanwhile, the catechol\u2010containing dual\u2010network architecture imparts strong wet adhesion and robust mechanical stability for conformal wound coverage. Mechanistically, this study provides, to our knowledge, the first evidence that thermoelectric stimulation reprograms fibroblast repair behavior through bioelectric transduction into a Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \/calmodulin\u2010dependent phosphoinositide 3\u2010kinase\/protein kinase B (PI3K\/Akt) and extracellular signal\u2010regulated kinase (Erk) signaling network. The hydrogel exhibits broad\u2010spectrum antibacterial activity, immunomodulatory effects, and pro\u2010angiogenic capacity in vitro, and accelerates wound healing by 66.84% in diabetic rats. This work establishes a self\u2010powered strategy that integrates bioelectric restoration with microenvironment remodeling for DFU repair.\n                  <\/jats:p>","DOI":"10.1002\/adma.73728","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:25:34Z","timestamp":1781331934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioelectric Reawakening by a Self\u2010Powered Thermoelectric Hydrogel Accelerates Diabetic Ulcer Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Wenqiang","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"},{"name":"Shanghai Sixth People's Hospital Anhui Campus  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Digital Twin Eastern Institute of Technology  Ningbo Zhejiang P. 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