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These CVs selectively target cancer cells via biotin\u2010mediated recognition. CVs of\u00a0\n                    <jats:bold>Biotin\u2010SR\u00a0<\/jats:bold>\n                    with pronounced morphological persistence, as confirmed by restricted molecular exchange in\u00a0FRAP analysis, and encapsulate glucose oxidase (GOx) within this stabilized vesicular architecture, undergo ALP\u2010induced enzymatic dephosphorylation in ALP\u2010rich tumor environments to trigger an\u00a0irreversible loss of charge complementarity, GOx release\u00a0and a synergistic therapeutic cascade integrating enzymatic starvation, oxidative stress amplification, and NO\u2010mediated mitochondrial dysfunction. The resulting glucose depletion couples with NO generation to elevate reactive oxygen species (ROS), inducing mitochondrial dysfunction and suppressing tumor growth in both spheroids and xenograft models. This work demonstrates how minimal peptide sequences can translate liquid\u2010liquid phase separation into stable coacervate vesicles with enzyme\u2010responsive supramolecular function for targeted therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/adma.73804","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T07:06:28Z","timestamp":1783321588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sequence\u2010Defined Short Peptide\u2010Derived Coacervate Vesicles for Targeted Therapeutics"],"prefix":"10.1002","volume":"38","author":[{"given":"Sandip","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences and Center for Advanced Functional Materials Indian Institute of Science Education and Research (IISER) Kolkata  Mohanpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajsekhar","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Bioscience &amp; Bioengineering Indian Institute of Technology  Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6469-9642","authenticated-orcid":false,"given":"Atin","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Center for Advanced Functional Materials Indian Institute of Science Education and Research (IISER) Kolkata  Mohanpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3935-6414","authenticated-orcid":false,"given":"Nityananda","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Bioscience &amp; Bioengineering Indian Institute of Technology  Jodhpur Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2709-8856","authenticated-orcid":false,"given":"Raviranjan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Indian Institute of Science Education and Research (IISER) Kolkata  Mohanpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubhajit","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Center for Advanced Functional Materials Indian Institute of Science Education and Research (IISER) Kolkata  Mohanpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batakrishna","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences and Center for Advanced Functional Materials Indian Institute of Science Education and Research (IISER) Kolkata  Mohanpur West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-4610","authenticated-orcid":false,"given":"Uttam","family":"Pal","sequence":"additional","affiliation":[{"name":"Technical Research Centre S. 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