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Although existing eye\u2010worn wearable sensors enable noninvasive IOP monitoring, limitations in sensitivity, closed\u2010eye performance, and overnight wearability restrict accurate assessment of nocturnal IOP changes under sleep conditions. Here, we present a soft contact lens sensor designed for continuous monitoring of nocturnal IOP in a home setting. The sensor integrates a compliant conductor\u2013based inductive\u2013capacitive circuit directly onto a commercial soft contact lens, enabling close conformity to the eye. This design achieves the highest IOP sensitivity reported to date among wearable soft contact lens sensors, representing a substantial improvement over our earlier designs. As a result, the sensor provides stable and accurate IOP measurements under recumbent, closed\u2010eye sleep conditions. Animal studies in rabbits and dogs and pilot human measurements in healthy and glaucomatous eyes support preliminary ocular tolerability and feasible sensor performance, enabling posture\u2010dependent IOP tracking and detection of sleep\u2010relevant pressure elevations under the tested conditions. These results address key limitations of earlier contact lens sensors and support at\u2010home monitoring of nocturnal IOP dynamics.<\/jats:p>","DOI":"10.1002\/adma.73813","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T17:03:42Z","timestamp":1782234222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nocturnal Intraocular Pressure Monitoring With a Soft Contact Lens Sensor for Glaucoma Management"],"prefix":"10.1002","volume":"38","author":[{"given":"Yumin","family":"Dai","sequence":"first","affiliation":[{"name":"School of Materials Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan Michael","family":"Long","sequence":"additional","affiliation":[{"name":"School of Optometry Indiana University  Bloomington IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwabunmi T.","family":"Oladele","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngoh","family":"Lee","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Li","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziheng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeonji","family":"Oh","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsang","family":"Lee","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taewoong","family":"Park","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhao","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Mechanical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokkyoon","family":"Hong","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeonghee","family":"Lim","sequence":"additional","affiliation":[{"name":"School of Materials Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinheon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Weldon School of Biomedical Engineering Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn Meyer","family":"Schneider","sequence":"additional","affiliation":[{"name":"School of Optometry Indiana University  Bloomington IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyerim","family":"Ra","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences Purdue University  West Lafayette IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan W.","family":"Boudouris","sequence":"additional","affiliation":[{"name":"Charles D. 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