{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:54:16Z","timestamp":1785772456233,"version":"3.56.0"},"reference-count":52,"publisher":"Wiley","issue":"43","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K01517"],"award-info":[{"award-number":["25K01517"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The extensive reliance on animal models in biomedical research motivates the development of advanced\u00a0in vitro\u00a0systems that recapitulate physiological complexity while minimizing animal use. Large cellular spheroids can mimic native tissue architecture; however, scalable fabrication of spheroids exceeding millimeter dimensions remains challenging. Here, we introduce a rigid porous capsule (RPC) in millimeter scale, a mechanically robust yet highly permeable platform that imposes external geometric confinement to enable cell\u2013cell aggregation and three\u2010dimensional proliferation. The RPC is fabricated by thermally processing LMs composed of a binary mixture of superhydrophobic particles: meltable poly(octadecyl acrylate) (PODAc) microparticles and non\u2010meltable bovine serum albumin (BSA) nanoparticles. Selective melting of PODAc induces a transformation of the initially fragile, porous LM shell into a rigid and macroporous architecture (pore size in \u00b5m scale). By modulating the binary mixture composition, the shell stiffness and porosity are precisely tuned to balance mechanical stability with efficient nutrient transport. The resulting RPCs retain a highly spherical geometry and support 3D cell culture for at least 14 days, enabling the formation of viable, scaffold\u2010free spheroids on a millimetric scale. This RPC establishes a physiologically relevant system for advanced tissue modeling and drug screening.<\/jats:p>","DOI":"10.1002\/adma.73815","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T13:27:38Z","timestamp":1782826058000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Composite Liquid Marble Templated Millimetric Capsule With Tunable Rigidity, Porosity, and Thermal Reconfigurability Toward 3D Cell Culture"],"prefix":"10.1002","volume":"38","author":[{"given":"Chittaranjan","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology Guwahati  Guwahati Assam India"},{"name":"Research Center For Materials Nanoarchitectonics (MANA) National Institute for Materials Science (NIMS)  Tsukuba Ibaraki 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