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However, most NIR\u2010activated AIEgens, especially donor\u2013acceptor\u2013donor (D\u2010A\u2010D) benzobisthiadiazole derivatives, are mainly used for bioimaging and photothermal therapy due to their intrinsically small S\n                    <jats:sub>1<\/jats:sub>\n                    \u2192S\n                    <jats:sub>0<\/jats:sub>\n                    energy gaps (\u0394\n                    <jats:italic>\n                      E\n                      <jats:sub>S1\u2010S0<\/jats:sub>\n                    <\/jats:italic>\n                    ) severely limiting reactive oxygen species (ROS) generation. Here, we present a strategy to convert widely adopted D\u2010A\u2010D NIR\u2010activated AIEgens into NIR\u2010activated type I PSs by conjugating nitric oxide (NO) to the electron\u2010donating units. Upon NO conjugation, the resulting compounds NO\u2010T\u2010TQT and NO\u20102TT\u2010\n                    <jats:italic>o<\/jats:italic>\n                    C6B become efficient generators of NIR\u2010activated hydroxyl radical (\u2022OH), exhibiting a 13.2\u2010fold and 5.4\u2010fold increase in superoxide (O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2022\u2212<\/jats:sup>\n                    ) production compared with their parent molecules, respectively. In contrast, T\u2010TQT, 2TT\u2010\n                    <jats:italic>o<\/jats:italic>\n                    C6B, and related analogues produce negligible ROS and no detectable \u2022OH. Mechanistic studies reveal that NO conjugation narrows the singlet\u2010triplet energy gap, strengthens spin\u2010orbit coupling to enhance intersystem crossing, optimizes redox potentials to favor electron transfer, and lowering hydrogen atom affinity. NO\u20102TT\u2010\n                    <jats:italic>o<\/jats:italic>\n                    C6B nanoparticles achieved potent in vitro cytotoxicity and effective in vivo tumor ablation under NIR irradiation. This work establishes a general approach to transform conventional NIR\u2010activated D\u2010A\u2010D AIEgens into high\u2010performance type I PSs, significantly advancing their clinical potential in PDT.\n                  <\/jats:p>","DOI":"10.1002\/adma.73860","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:48:47Z","timestamp":1782449327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Nitric Oxide Conjugation Transforms NIR\u2010II AIEgens Into Potent Hypoxia\u2010Tolerant Type I Photosensitizers"],"prefix":"10.1002","volume":"38","author":[{"given":"Junjun","family":"Ni","sequence":"first","affiliation":[{"name":"Bioinspired Engineering and Biomechanics Center (BEBC) School of Life Science and Technology The Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi'an Jiaotong University  Xi'an P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky W. Y.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Division of Life Science State Key Laboratory of Nervous System Disorders, and Department of Chemical and Biological Engineering The Hong Kong University of Science &amp; Technology  Kowloon Hong Kong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianrui","family":"Hu","sequence":"additional","affiliation":[{"name":"Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Shanghai Frontiers Science Center of Molecule Intelligent Syntheses School of Chemistry and Molecular Engineering East China Normal University  Shanghai P. R. 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