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Inspired by the dynamic metal homeostasis of metallothioneins, we propose a\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010hydroxy thioether\u2013based ion\u2010regulatory network that programs competing binding sites with distinct kinetic and thermodynamic preferences, thereby embedding an intrinsic functional clock into an otherwise static material. As a proof of concept, silver is employed as a representative ion to demonstrate how conventional metal bactericides can be transformed into stage\u2010adaptive defense factors. Initially, the system is dominated by labile hydroxyl complexation, triggering silver ion release under infection\u2010associated acidification and enabling rapid bactericidal clearance. Over time, the system shifts toward thermodynamically favored thioether coordination, which becomes dominant and reprograms the coating, resulting in bacterial repulsion and mineral exclusion at sub\u2010bactericidal ion levels. The stage\u2010adaptive protection is validated in methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    \u2010infected wound and long\u2010term (3\u2010month) bladder indwelling models. This work establishes time\u2010programmable ion regulation as an extensible design concept for adaptive biomaterials capable of coping with evolving biological environments.\n                  <\/jats:p>","DOI":"10.1002\/adma.73872","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:40:45Z","timestamp":1782448845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metallothionein\u2010Inspired Dual\u2010Stage Ion\u2010Regulatory Coatings With Infection\u2010Triggered Bactericidal Activity and Long\u2010Term Antifouling Protection"],"prefix":"10.1002","volume":"38","author":[{"given":"Jinghua","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan Hubei P. R. 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