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However, the absence of a stable electrode interface compatible with pathologically xerotic skin has hindered this approach. Here, we develop a conformable neuromotor electrode interface that overcomes this via molecular engineering, exhibiting an ultrasoft modulus (\u223c 2.13 kPa), low impedance (\u223c 0.9 k\u03a9 at 1 kHz), and stable electrical retention over 7 days. This interface enables the acquisition of high\u2010fidelity sEMG from dermatomyositis patients with low baseline noise (&lt; 2 \u00b5V root mean square) and high inter\u2010channel signal correlation, allowing robust decomposition of neuromotor biomarkers including motor unit count, action potential amplitude, and firing rate. Clinically, our multi\u2010biomarker quantification strategy shows strong agreement with gold standard assessments. Moreover, our approach can detect subtle interpatient variations like early recruitment patterns, enabling personalized treatment beyond the clinical gold standard. This work establishes a transformative platform for precise muscle weakness evaluation, overcoming the limitations of needle electromyography and subjective clinical scales.<\/jats:p>","DOI":"10.1002\/adma.73874","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T11:17:31Z","timestamp":1782731851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Xerotic Skin\u2010Compatible Neuromotor Electrode Interface for Non\u2010Invasive Muscle Weakness Evaluation in Dermatomyositis"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5791-4360","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Integrated Chips and Systems Frontier Institute of Chip and System College of Integrated Circuits and Micro\u2010Nano Electronics Fudan University  Shanghai P. R. 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