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However, their widespread adoption has been limited by the intrinsic instability and high cost of natural glucose oxidase (GOx). Although nanozymes offer a more robust alternative, their lack of substrate specificity is a major challenge. Herein, a manganese\u2010based tannic acid single\u2010atom nanozyme (TA\u2010Mn SA) with a dual biomimetic architecture was developed. It features atomically dispersed Mn catalytic sites embedded within a tannic acid\u2010derived molecular pocket tailored for selective glucose recognition. This engineered enzyme mimic exhibits exceptional catalytic efficiency and substrate selectivity. The origin of this selectivity and the catalytic cycle were elucidated through both experimental data and density functional theory calculations. When integrated into a wearable sweat sensor, the TA\u2010Mn SA nanozyme reliably tracked blood glucose levels in human trials, capturing personalized metabolic dynamics during fasting, feeding, and exercise. This design is inherently compatible with scalable, low\u2010cost manufacturing, paving the way for a new era of accessible continuous glucose monitoring.<\/jats:p>","DOI":"10.1002\/adma.73876","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:53:07Z","timestamp":1782445987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Biomimetic Single\u2010Atom Nanozyme With a Substrate Pocket for Accurate and Continuous Sweat Glucose Monitoring"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiaoyan","family":"Wang","sequence":"first","affiliation":[{"name":"Experimental Center of Advanced Materials School of Materials Science &amp; Engineering Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Spacecraft System Engineering China 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