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Herein, we report an in situ H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010activated plasmonic nanozyme, Cu\n                    <jats:sub>2<\/jats:sub>\n                    O\u2010HTB@D, fabricated by co\u2010loading Cu\n                    <jats:sub>2<\/jats:sub>\n                    O nanoparticles and 4\u2010hydroxythiobenzamide (4\u2010HTB) into tetrasulfide\u2010rich dendritic mesoporous organosilica nanoparticles (DMONs) for near\u2010infrared II (NIR\u2010II) plasmonic thermoelectric (PTE) cancer catalytic therapy. Upon accumulation in the tumor microenvironment, the tetrasulfide\u2010rich DMON framework reacts with overexpressed glutathione (GSH), triggering structural disintegration and release of Cu\n                    <jats:sub>2<\/jats:sub>\n                    O and 4\u2010HTB. Subsequently, H\n                    <jats:sub>2<\/jats:sub>\n                    S generated from the reaction of DMONs and 4\u2010HTB with GSH induces in situ conversion of Cu\n                    <jats:sub>2<\/jats:sub>\n                    O into Cu\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    S. The resulting Cu\n                    <jats:sub>2\u2010x<\/jats:sub>\n                    S exhibits strong NIR\u2010II plasmonic and PTE properties with peroxidase\u2010, catalase\u2010 and oxidase\u2010like multi\u2010enzymatic activities, enabling robust \u2219OH and \u02d9O\n                    <jats:sub>2<\/jats:sub>\n                    \u203e generation amplified by plasmonic hyperthermia and PTE effects under 1064 nm laser irradiation. In vivo studies demonstrate exceptional tumor suppression in a triple\u2010negative breast cancer murine model with high targeting specificity and minimal systemic toxicity after intravenous administration of Cu\n                    <jats:sub>2<\/jats:sub>\n                    O\u2010HTB@D. This strategy highlights a clinically translatable approach for spatially controlled catalytic therapy via in situ generation of plasmonic nanozymes.\n                  <\/jats:p>","DOI":"10.1002\/adma.73898","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:21:46Z","timestamp":1783081306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An In Situ H\n                    <sub>2<\/sub>\n                    S\u2010Activated Plasmonic Nanozyme for Near\u2010Infrared II Photo\u2010Thermoelectric Catalytic Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Jinghang","family":"Li","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"School of Materials 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