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Herein, we present a facile surface\u2010engineering strategy to construct a multifunctional PEEK\u2010based implant by introducing manganese\u2010chelated polydopamine (Mn@p) and mesoporous bioactive glass nanoparticles (MBGNs) onto sulfonated PEEK (SPEEK). The resulting Mn@p\/MBG\u2010SPEEK exhibits a hierarchically porous three\u2010dimensional architecture with markedly enhanced hydrophilicity and surface roughness. This tailored interface shows in vitro bioactivity and cytocompatibility, significantly promoting the osteogenic differentiation of MC3T3\u2010E1 cells through the activation of PI3K\/Akt\/mTOR and AP\u20101 signaling pathways, as evidenced by the upregulation of ALP, OCN, OPN, and Runx2 expression. Meanwhile, the pro\u2010angiogenic potential of Mn@p\/MBG\u2010SPEEK is supported by the upregulation of VEGF and CD31 in HUVECs and enhanced capillary\u2010like network formation. Notably, Mn@p\/MBG\u2010SPEEK demonstrates efficient light\u2010to\u2010heat conversion and potent antibacterial efficacy against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    under near\u2010infrared (NIR) irradiation. Density functional theory (DFT) calculations further reveal that Mn chelation narrows the HOMO\u2010LUMO energy gap and facilitates charge separation, thereby amplifying photothermal and ROS\u2010mediated antibacterial effects. Collectively, this study establishes a versatile and scalable route to enhance the biological performance of PEEK implants, offering a conceptual framework for integrating ion\u2010assisted therapy with phototherapy toward next\u2010generation bioactive and infection\u2010resistant orthopedic materials.\n                  <\/jats:p>","DOI":"10.1002\/adma.73945","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:27:11Z","timestamp":1783582031000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Ion\u2010Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR\u2010Mediated Antibacterial Activity of PEEK"],"prefix":"10.1002","volume":"38","author":[{"given":"Zhiyan","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Biomaterials Department of Materials Science and Engineering University of Erlangen\u2010Nuremberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ond\u0159ej","family":"Adam","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering Technicka 2 Brno University of Technology  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Doubrava","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering Technicka 2 Brno University of Technology  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Departamento de Ingenier\u00eda y Ciencia de los Materiales y del Transporte Escuela Polit\u00e9cnica Superior Universidad de Sevilla  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8053-8489","authenticated-orcid":false,"given":"Ivo","family":"Dlouh\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Materials Science and Engineering Technicka 2 Brno University of Technology  Brno Czech Republic"},{"name":"Institute of Physics of Materials Czech Academy of Sciences  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-3766","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dental Materials Shanghai Biomaterials Research &amp; Testing Center College of Stomatology National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai Jiao Tong University Shanghai Key Laboratory of Stomatology  Shanghai P. 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