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Here, inspired by the functions of natural macrophages, we report the\n                    <jats:italic>de novo<\/jats:italic>\n                    design of an Ir\/TiN\u2010based photothermal\u2010activable artificial macrophage (ITN Art\u2010M) with enhanced systemic antibacterial activity to combat primary and secondary infections caused by antibiotic\u2010resistant bacteria. The experimental studies and theoretical calculations reveal that the ITN Art\u2010M displays spiky topology, robust photothermal properties, and electron\u2010rich Ir\u2010Ti catalytic sites for reactive oxygen species (ROS) production, which can efficiently capture and kill antibiotic\u2010resistant bacteria. Meanwhile, the synthesized ITN Art\u2010M can induce severe bacterial antigen leakage and exposure through synergistic oxidative and hyperthermic stress, thereby potently stimulating systemic antibacterial responses, assisting in the elimination of primary infections and establishing durable defensive surveillance against secondary infections. Notably, ITN Art\u2010M demonstrates superior\n                    <jats:italic>MRSA<\/jats:italic>\n                    eradication and recurrence prevention, offering a potent, intelligent alternative that may surpass conventional antibiotics in combating bacteria and many other pathogenic cells.\n                  <\/jats:p>","DOI":"10.1002\/adma.73989","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:20:35Z","timestamp":1783423235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photothermal\u2010Activable Artificial Macrophage With Amplified Systemic Antibacterial Responses to Combat Primary and Secondary Infection"],"prefix":"10.1002","volume":"38","author":[{"given":"Jiangge","family":"Li","sequence":"first","affiliation":[{"name":"College of Biomedical Engineering, National Engineering Research Center for Biomaterials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutong","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihuan","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjia","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Adeli","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry Free University of Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7414-630X","authenticated-orcid":false,"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, State Key Laboratory of Advanced Polymer Materials Sichuan University  Chengdu 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