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Herein, we propose a mechano\u2010electro\u2010chemical energy conversion paradigm based on an atomic\u2010to\u2010nanoscale synergistic strategy, realized by constructing a heterojunction between sulfur\u2010doped zinc oxide and bismuth ferrite (S\u2010ZnO\/BiFeO\n                    <jats:sub>3<\/jats:sub>\n                    ). At the atomic level, sulfur doping induces lattice distortion and oxygen vacancies, narrowing the bandgap of ZnO. At the nanoscale level, sulfur doping modulates crystal growth, transforming ZnO nanoblocks into thinner nanosheets that establish intimate interfacial coupling with BiFeO\n                    <jats:sub>3<\/jats:sub>\n                    . This dual\u2010scale synergy amplifies the piezoelectric coefficient (d\n                    <jats:sub>33<\/jats:sub>\n                    ) tenfold, significantly enhancing the ultrasound (US)\u2010responsive piezocatalytic output. Under US, the enhanced piezocatalytic field facilitates directional charge migration and continuous reactive oxygen species (ROS) generation, achieving a 99.45% antibacterial rate against MRSA while effectively inhibiting biofilm growth. Transcriptomic profiling reveals that this energy conversion process eliminates MRSA via a multi\u2010target collapse of membrane defense, ion homeostasis, and energy metabolism. Concurrently, S\u2010ZnO\/BiFeO\n                    <jats:sub>3<\/jats:sub>\n                    promotes osteogenic differentiation through US\u2010triggered microcurrents and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    release. In vivo results validated robust bactericidal potency, osseointegrative kinetics, and excellent biocompatibility. This study establishes a mechano\u2010electro\u2010chemical energy conversion paradigm via atomic\u2010to\u2010nanoscale engineering, offering a high\u2010performance platform for precise piezocatalytic therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.74020","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T06:16:13Z","timestamp":1783664173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atomic\u2010to\u2010Nanoscale Engineering of Piezocatalytic Heterojunctions for Ultrasound\u2010Triggered Osteomyelitis Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Lijing","family":"Chen","sequence":"first","affiliation":[{"name":"School of Health Science and Biomedical Engineering Hebei University of Technology  Tianjin 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Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science and Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science and Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry\u2010of\u2010Education Key Laboratory For the Green Preparation and Application of Functional Materials School of Materials Science and Engineering State Key Laboratory of Biocatalysis and Enzyme Engineering Hubei University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talante","family":"Juma","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Peking University First Hospital  Beijing 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