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However, its actual efficacy is limited by compensatory oxidative phosphorylation (OXPHOS) energy replenishment and low delivery efficiency. Herein, we report a hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S)\u2010self\u2010supplying nanoplatform that orchestrates a dual blockade of glycolysis and OXPHOS for improved triple\u2010negative breast cancer (TNBC) immunotherapy. The micellar system, HA\u2010ADT@W, achieves tumor\u2010targeted delivery of a glycolysis inhibitor (WZB117) and H\n                    <jats:sub>2<\/jats:sub>\n                    S continually released in GSH\u2010overexpressed tumor cells. This strategy concurrently suppresses glucose uptake in tumor cells by reversing the acidic tumor microenvironment (TME) and disrupts compensatory OXPHOS via H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2010mediated inhibition of cytochrome c oxidase. Consequently, we demonstrate a significant rewiring of tumor energy metabolism that not only induces immunogenic cell death with remodeling of the immunosuppressive TME but also alleviates nutrient constraints of immune effector cells, leading to enhanced infiltration and function of cytotoxic immune cells. This work exhibits a smart nanoplatform\u2010based H\n                    <jats:sub>2<\/jats:sub>\n                    S self\u2010supplied micelle for reinforced TNBC immunotherapy via regulated metabolic competition between tumors and immune effector cells with TME normalization.\n                  <\/jats:p>","DOI":"10.1002\/adma.74041","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:31:51Z","timestamp":1783431111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["H\n                    <sub>2<\/sub>\n                    S Self\u2010Supplied Micelles Reverse Tumor\u2010Immune Effector Cells Energy Metabolisms to Boost Breast Cancer Immunotherapy With Microenvironment Normalization"],"prefix":"10.1002","volume":"38","author":[{"given":"Siyu","family":"Meng","sequence":"first","affiliation":[{"name":"School of Life Science and Technology Northwestern Polytechnical 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