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Herein, this work proposes a self\u2010stabilizing, water\u2010responsive coacervate powder composed of coenzyme\u2010based polymers (\u03b1\u2010lipoic acid\/sodium \u03b1\u2010lipoate, PLA\/Na), tannic acid (TA), and \u03b5\u2010polylysine (PLys), abbreviated as PLA\/Na@TA\/PLys,\u00a0to provide a one\u2010stop solution for rapid tissue sealing under challenging environments (e.g., wet, contaminated, intraoperative, or irregular wounds), and for improved healthcare outcomes. Upon hydration, the powder undergoes ultra\u2010rapid self\u2010gelation (&lt;10 s), conformally adhering to irregular wet tissues with exceptional performance (adhesion strength: 69.55\u00a0kPa; burst pressure: 216.23\u00a0mmHg). It achieves rapid hemostasis (&lt;20 s) in arterial, tail transection, and non\u2010compressible visceral bleeding models (liver, spleen, heart) with no rebleeding, outperforming commercial hemostats. Additionally, the powder exhibits broad\u2010spectrum antibacterial\/anti\u2010biofilm activity and promotes vascular endothelial cell viability, migration, and angiogenesis. In full\u2010thickness skin defects, it accelerates wound healing by mitigating inflammation and stimulating regeneration. With its facile storage, convenient application, and high biosafety, PLA\/Na@TA\/PLys represents a versatile bioadhesive with significant translational potential for emergency hemostasis, infection prevention, and tissue repair in clinical settings.<\/jats:p>","DOI":"10.1002\/adma.74107","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:44:34Z","timestamp":1784897074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Situ Coenzyme\u2010Based Transformable Polymers Powder With Instant\u2010Tough\u2010Adhesive Properties for Emergency Hemostasis, Antibiosis, and Wound Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Cong","family":"Li","sequence":"first","affiliation":[{"name":"Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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