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Here, we report a universal sacrificial\u2010support\u2010assisted TPL approach enabled by a newly developed water\u2010soluble (W\u2010S) photoresist. The W\u2010S photoresist integrates high printing resolution with rapid dissolution, allowing sacrificial scaffolds to be completely removed in mild aqueous media within 10\u00a0min. To the best of our knowledge, this represents one of the fastest dissolution performances achieved under such gentle conditions among reported dissolvable photoresists for TPL. This combination of structural stability under dry conditions and rapid aqueous removability decouples fabrication fidelity from post\u2010processing constraints, thereby enabling unconstrained 3D microfabrication. As representative demonstrations, long single\u2010clamped cantilevers and micro\u2010biconvex lenses were fabricated with high geometric fidelity and surface smoothness. After selective removal of the soluble supports, the microstructures retained precise morphology and exhibited excellent optical performance. Overall, this work introduces a rapidly dissolvable photoresist and establishes a versatile materials\u2010enabled fabrication strategy for constructing previously inaccessible 3D microarchitectures, opening new opportunities in micro\u2010optics, photonics, and bio\u2010integrated systems.<\/jats:p>","DOI":"10.1002\/adma.74112","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:37:18Z","timestamp":1784104638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Water\u2010Soluble Sacrificial Scaffolds for Unconstrained 3D Microfabrication via Two\u2010Photon Lithography"],"prefix":"10.1002","volume":"38","author":[{"given":"Zhongying","family":"Ji","sequence":"first","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"You","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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Ravindu","family":"Nanayakkara","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry The University of Arizona  Tucson Arizona USA"},{"name":"Department of Materials Science &amp; Engineering The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Chen","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bofan","family":"Song","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Hong","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Loy","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Biochemistry The University of Arizona  Tucson Arizona USA"},{"name":"Department of Materials Science &amp; Engineering The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-3457","authenticated-orcid":false,"given":"Rongguang","family":"Liang","sequence":"additional","affiliation":[{"name":"Wyant College of Optical Sciences The University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105595"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214211"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202204072"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/2631\u20107990\/ad9dc0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586\u2010025\u201000386\u2010y"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201052929\u20108"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/lsa.2017.134"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2026.105178"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510834"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202409859"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046743\u20105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2023.103474"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym15081816"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202214409"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add7023"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201062674\u20101"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.148027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202504475"},{"key":"e_1_2_9_21_1","article-title":"Sacrificial Biofabrication for Vascularization: Concept, Materials, Technologies, and Applications","volume":"38","author":"Shi J.","year":"2025","journal-title":"Advanced Materials"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010018\u201005234\u20100"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202203474"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202414713"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056984\u20107"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202206303"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/2631\u20107990\/acfc03"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","unstructured":"C. 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