{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:07:34Z","timestamp":1790172454661,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"48","license":[{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M743054"],"award-info":[{"award-number":["2023M743054"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydrogel metamaterials with programmable microarchitectures offer a promising route for converting molecular recognition into mechanical responses. However, efficiently transducing weak biomolecular perturbations into detectable signals without relying on molecular amplification remains a fundamental challenge. Here, we report a metamaterial Buckling\u2010Assisted Surface\u2010acoustic\u2010wave Enabled Sensor (mBASES), which introduces a structure\u2010triggered physical amplification mechanism by integrating bio\u2010crosslinked hydrogel metamaterials with a surface acoustic wave (SAW) device. Through competitive biomolecular recognition, target binding induces hydrogel swelling that is engineered to match the critical buckling threshold of the metamaterial. This instability\u2010enabled pattern transformation acts as an intrinsic mechanical gain element, converting weak molecular perturbations into amplified acoustic responses through coupled modulation of phononic transmission and hydrogel\u2013SAW interactions. As a result, mBASES establishes a transduction pathway that links molecular recognition, hydrogel deformation, structural amplification, and ultimately acoustic readout. The platform enables rapid, label\u2010free detection across multiple biomolecular classes, including proteins, nucleic acids, and metabolites. Clinical validation further demonstrates femtomolar\u2010level detection of Herpes Simplex Virus (HSV) IgG and unamplified DNA in human serum within 5\u201315\u00a0min using a one\u2010step assay. By amplifying the transduction process rather than the target molecules, mBASES establishes a versatile biosensing strategy, providing a promising platform for point\u2010of\u2010care diagnostics.<\/jats:p>","DOI":"10.1002\/adma.74198","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:58:40Z","timestamp":1784534320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Metamaterial Buckling\u2010Assisted Surface\u2010Acoustic\u2010Wave Enabled Sensor (mBASES) for Versatile and Ultrasensitive Biomarker Detection"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9613-9273","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory for Biomedical Engineering of Education Ministry Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument College of Biomedical Engineering &amp; Instrument Science Zhejiang University Hangzhou P. 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