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However, their development faces persistent challenges, including the laborious and costly process of neoantigen identification, which substantially delays vaccine production. Moreover, conventional platforms suffer from rapid systemic clearance and inefficient delivery to antigen\u2010presenting cells (APCs), leading to only transient and weak immune activation. Here, we report a STING\u2010agonist\u2010integrated hydrogel system designed for localized delivery of tumor\u2010derived extracellular vesicles (TEVs) to achieve robust and durable antitumor immunity. Upon subcutaneous administration, the in situ formed hydrogel vaccine acts as a depot for antigen\u2010rich TEVs and STING agonists. We demonstrate that this vaccine promotes dendritic cells (DCs) recruitment and establishes an immune\u2010permissive niche through spatiotemporal control over antigen\u2010adjuvant distribution and prolonged APC\u2010antigen engagement. Within this niche, DCs efficiently internalize and process TEVs under STING\u2010mediated activation. These matured DCs subsequently migrate to draining lymph nodes, where they initiate potent and sustained tumor\u2010specific T\u2010cell responses. Our results show that rapidly producible personalized vaccines derived from melanoma TEVs effectively inhibit tumor growth. In a postoperative breast cancer model, patient\u2010tailored TEV vaccines also markedly prevent tumor recurrence and metastasis. This readily customizable platform represents a robust and translatable strategy for personalized cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.74204","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:53:26Z","timestamp":1784375606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Supramolecular STING\u2010Hydrogel Spatiotemporally Boosts Tumor\u2010Derived Extracellular Vesicle\u2010Based Personalized Vaccine for Enhanced Cancer Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Minglu","family":"Tang","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8682-2380","authenticated-orcid":false,"given":"Chenwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of 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