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Clinical monitoring methods show notable delays, while real\u2010time blood monitoring devices fail to ensure long\u2010term stability in vivo. Here, we present a chemical\u2010sensing catheter that integrates multiple analyte sensors, including creatinine, taurocholic acid, bilirubin, and taurine, for real\u2010time monitoring of complications in patients receiving long\u2010term chemotherapy or parenteral nutrition in situ. The design of the metalgel preserves signal integrity through 1 million bending deformations, and a dual\u2010network molecularly imprinted polymer suppresses in vivo performance degradation, enabling stable long\u2010term operation of the chemical\u2010sensing catheter over a 3 month implantation period. In chemotherapy and parenteral nutrition applications, early monitoring of liver and kidney injury, combined with prognostic intervention, mitigates risks such as bile stasis, hepatitis, and hepatic steatosis. With the integration of machine learning analysis of multimodal sensor data, this technology provides early prediction of complications and establishes a new paradigm for personalized therapeutic management.<\/jats:p>","DOI":"10.1002\/adma.74221","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:00:38Z","timestamp":1784728838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical\u2010Sensing Catheters for Long\u2010Term and Personalized Therapeutic Management"],"prefix":"10.1002","volume":"38","author":[{"given":"Yiran","family":"Li","sequence":"first","affiliation":[{"name":"National Laboratory of Solid\u2010State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University  Nanjing 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Engineering and Applied Sciences Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangyi","family":"Zou","sequence":"additional","affiliation":[{"name":"National Laboratory of Solid\u2010State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Inflammation and Immunoregulation School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxuan","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Artificial Intelligence Nankai University  Tianjin 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