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The photocatalytic generation of hydroxyl radicals (\u2022OH) represents a green and powerful route for bacterial inactivation, yet its efficiency is often limited by the sluggish kinetics of the stepwise single\u2010electron oxygen reduction pathway. Herein, we report an atomic\u2010level design strategy by anchoring asymmetric Zn\u2500N\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>1<\/jats:sub>\n                    sites onto ultrathin graphitic carbon nitride nanosheets (Zn\n                    <jats:sub>1<\/jats:sub>\n                    \/OCN) to accelerate \u2022OH production. The introduced Zn\u2500N\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>1<\/jats:sub>\n                    sites create localized intermediate states that enable rapid trapping of photogenerated electrons at Zn single\u2010atom sites and prolong their lifetime, thereby driving a stepwise single\u2010electron oxygen reduction reaction (ORR) for efficient \u2022OH generation. Simultaneously, adjacent C\u2550O moieties act as hole\u2010trapping centers to drive water oxidation reaction (WOR), establishing a local reservoir of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and protons that couples with the ORR process, thus forming a cooperative redox pathway for enhanced \u2022OH production. Additionally, these asymmetric sites effectively lower the formation energies of *OOH and *OH intermediates, thereby accelerating both ORR and WOR processes and facilitating \u2022OH generation. Consequently, Zn\n                    <jats:sub>1<\/jats:sub>\n                    \/OCN achieves outstanding bactericidal performance, inactivating 99.9% of drug\u2010resistant bacteria, within 30 min under natural light, markedly outperforming representative photocatalytic antibacterial materials reported to date.\n                  <\/jats:p>","DOI":"10.1002\/adma.74222","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T12:01:45Z","timestamp":1784376105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Asymmetric Zn\u2500N\n                    <sub>3<\/sub>\n                    O\n                    <sub>1<\/sub>\n                    Single\u2010Atom Sites Promote Hydroxyl Radical Generation for Natural\u2010Light\u2010Driven Inactivation of Drug\u2010Resistant Bacteria"],"prefix":"10.1002","volume":"38","author":[{"given":"ShaoSheng","family":"Rao","sequence":"first","affiliation":[{"name":"School of Chemistry and Materials Jiangxi Agricultural University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XiaoChun","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Jiangsu University  Zhenjiang Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChuanFa","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Jiangxi Agricultural University  Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Min","sequence":"additional","affiliation":[{"name":"School of Chemistry and Materials Jiangxi Agricultural University  Nanchang Jiangxi 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