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Nevertheless, its commercialization is constrained by multi\u2010scale failure mechanisms that operate across scales ranging from atoms to entire systems, including catalyst dissolution and reconstruction, degradation of the three\u2010phase interface with membrane electrode assemblies, corrosion of bipolar plates, and uneven stack assembly. This review systematically investigates the failure behaviors of AEM electrolyzers across multiple scales and introduces a collaborative design strategy spanning from the atomic to the system level. By integrating innovative membrane\u2010electrode architectures, biomimetic flow\u2010field designs, and advanced intelligent control systems, we establish a full\u2010chain optimization scheme spanning materials, devices, and systems that simultaneously improves current density, durability, and dynamic response. Emphasizing the critical roles of in situ characterization and artificial intelligence in elucidating failure mechanisms and enabling predictive control. This review also provides a systematic multi\u2010scale design blueprint and a technical pathway for transitioning AEMWE from laboratory\u2010scale prototypes (\u201cLab\u201d) to gigawatt\u2010scale fabrication facilities (\u201cFab\u201d). Ultimately, it aims to facilitate the adoption of AEMWE as an efficient and reliable industrial solution for the green hydrogen economy.<\/jats:p>","DOI":"10.1002\/adma.74223","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T16:49:06Z","timestamp":1784738946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Lab to Fab: Path Forward for Multi\u2010Scale Design of Industrial Anion Exchange Membrane Electrolyzers"],"prefix":"10.1002","volume":"38","author":[{"given":"Qingzhu","family":"Shu","sequence":"first","affiliation":[{"name":"Petroleum and Chemical Industry Key Laboratory of Organic Electrochemical Synthesis College of Chemical Engineering Zhejiang University of Technology (ZJUT)  Hangzhou P. R. 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