{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:06:17Z","timestamp":1789682777231,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"49","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473106"],"award-info":[{"award-number":["52473106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20314"],"award-info":[{"award-number":["U22A20314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571067"],"award-info":[{"award-number":["82571067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024IAIS\u2010QN003"],"award-info":[{"award-number":["2024IAIS\u2010QN003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bioactive molecules can self\u2010assemble to form noncentrosymmetric supramolecular materials exhibiting piezoelectric response. However, the piezoelectricity of antibiotic\u2010based molecular assemblies has been largely unexplored. The understanding of the structure\u2010piezoelectricity relationship of bioactive molecular assemblies will facilitate the rational design of multifunctional piezoelectric materials. Herein, for the first time, we systematically investigated the piezoelectricity of bioactive \u03b2\u2010lactam drug\u2010based supramolecular assemblies, further revealing the piezoelectric\u2010antibacterial synergy of electronic devices. X\u2010ray diffraction analysis revealed that the supramolecular assemblies of different \u03b2\u2010lactam drugs exhibited diverse ordered packing modes. Their maximum piezoelectric coefficients showed a broad range of 3.2\u201344.3 pC N\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    as calculated by density functional theory, in which faropenem sodium (FarNa) crystals displayed the highest value due to a highly asymmetric structure and a large dipole alignment. The FarNa crystal\u2010based piezoelectric device generated an open\u2010circuit voltage of up to 1.08\u00a0V and was successfully integrated into a flexible sensor for rehabilitation monitoring. Furthermore, the piezoelectric response of composite films loaded with amoxicillin (AMX) or FarNa crystals could disrupt bacterial cell membranes, enhancing antibacterial activity and infected wound healing. This work explores the piezoelectric response of \u03b2\u2010lactam drug\u2010based assemblies, leveraging a supramolecular assembly strategy to develop biomaterials with coupled piezoelectric and biological functions.\n                  <\/jats:p>","DOI":"10.1002\/adma.74237","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:59:12Z","timestamp":1784721552000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Piezoelectric Bioactive Drug\u2010Based Supramolecular Assemblies Toward Health Monitoring and Wound Healing"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiaoyu","family":"Tong","sequence":"first","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University  Chongqing 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Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0224-6640","authenticated-orcid":false,"given":"Jinlin","family":"Song","sequence":"additional","affiliation":[{"name":"The Affiliated Stomatological Hospital of Chongqing Medical University Chongqing Key Laboratory of Oral Diseases Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8982-5460","authenticated-orcid":false,"given":"Wei","family":"Ji","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering Chongqing University  Chongqing 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