{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:11:39Z","timestamp":1790151099338,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"52","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20314,82401124"],"award-info":[{"award-number":["U22A20314,82401124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009976","name":"Chongqing Municipal Postdoctoral Science Special Foundation","doi-asserted-by":"publisher","award":["2024CQBSHTB3111"],"award-info":[{"award-number":["2024CQBSHTB3111"]}],"id":[{"id":"10.13039\/501100009976","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M771772"],"award-info":[{"award-number":["2025M771772"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bio\u2010proteins with intrinsic piezoelectricity are highly promising for bioelectronics due to their tunable conformations, biocompatibility, and biodegradability. However, their practical applications are severely constrained by difficulties in regulating piezoelectric domains and inherent mechanical brittleness. In this study, we propose a small\u2010molecule dual\u2010amplifier strategy to achieve high performance piezoelectric biomaterials. By introducing a dopamine\u2010mediated modulation approach, a silk fibroin\u2010based film with an enhanced piezoelectric coefficient of up to 12.7 pC N\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    is obtained. This performance boost is attributed to a dual mechanism: the dopamine\u2010induced promotion of \u03b2\u2010sheet formation in silk fibroin, which strengthens its intrinsic piezoelectricity, and the synergistic contribution of piezoelectric dipole moments from dopamine. In addition, the film exhibits superior mechanical robustness and flexibility, tunable stability in aqueous environments, as well as excellent in vitro\/vivo biocompatibility. When applied to the sensing of temporomandibular joint motion and oral occlusal contact patterns, the resulting sensors demonstrate high sensitivity and long\u2010term stability. Furthermore, the generated voltage signals can be effectively encoded and converted into digital information, facilitating data processing and analysis. These results demonstrate small\u2010molecule modulation represents a reliable approach for enhancing the piezoelectricity of structurally complex proteins, offering a simple and innovative pathway toward the development of high\u2010performance bio\u2010piezoelectric materials for digital healthcare.\n                  <\/jats:p>","DOI":"10.1002\/adma.74240","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:13:36Z","timestamp":1785492816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Dopamine Driven Dual\u2010Amplifier Strategy for High Performance Bioorganic Piezoelectrics via Secondary\u2010Structure Modulation and Synergistic Molecular Dipoles"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-2997","authenticated-orcid":false,"given":"Xin","family":"Tan","sequence":"first","affiliation":[{"name":"College of Stomatology, Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education Chongqing Medical University  Chongqing P. 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