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However, their ROS generation is fundamentally limited by the low photon energy of long\u2010wavelength excitation and the hypoxic tumor microenvironment. Herein, we report three oxygen\u2010regenerative NIR aza\u2010BODIPY PSs for efficient hypoxia\u2010tolerant PDT under 808 nm excitation. Mechanistic studies identify PS radical\u2010ion pairs as the key intermediates that couple water oxidation\u2010driven in situ O\n                    <jats:sub>2<\/jats:sub>\n                    \/proton (H\n                    <jats:sup>+<\/jats:sup>\n                    ) generation with downstream oxygen reduction to enable efficient hypoxia\u2010tolerant \u2022OH production. In parallel, efficient H\n                    <jats:sup>+<\/jats:sup>\n                    generation and strong H\n                    <jats:sup>+<\/jats:sup>\n                    affinity of the target PS (\n                    <jats:bold>NJ853<\/jats:bold>\n                    ) promote H\n                    <jats:sup>+<\/jats:sup>\n                    \u2010engaged oxygen photoreduction, affording a \u223c56\u2010fold enhancement in \u2022OH generation compared with commercial PS indocyanine green (ICG). This hypoxia\u2010tolerant intracellular ROS generation enables\n                    <jats:bold>NJ853@NPs<\/jats:bold>\n                    to induce apoptosis\u2010dominant cancer cell killing and superior in vivo PDT efficacy under 808 nm irradiation. This work establishes an oxygen\u2010regenerative photoredox pathway for NIR PSs, opening a new avenue to overcome the longstanding hypoxia limitation in deep\u2010tissue PDT.\n                  <\/jats:p>","DOI":"10.1002\/adma.74272","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:27:36Z","timestamp":1785241656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen\u2010Regenerative NIR Aza\u2010BODIPY Photosensitizers for Hypoxia\u2010Tolerant Photodynamic Therapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3923-814X","authenticated-orcid":false,"given":"Yi","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) School of Flexible Electronics (SFE) Northwestern Polytechnical University  Xi'an 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Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Miao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Advanced Materials (IAM) Nanjing University of Posts &amp; Telecommunications  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Flexible Electronics (KLOFE) Institute of Advanced Materials (IAM) Nanjing Tech University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Flexible Electronics (KLOFE) Institute of Advanced Materials (IAM) Nanjing Tech University  Nanjing 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