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However, achieving precisely controllable bioelectronic ablation remains challenging. Here, we report a living bioelectronic platform, termed PSDT, for radiotherapy (RT)\u2010activated tumor intervention and immune activation. PSDT consists of a Pd\/Pt\u2010modified\n                    <jats:italic>Shewanella<\/jats:italic>\n                    core (SDT) encapsulated within a ROS\u2010responsive polymeric shell (PEI\u2010Se\u2010Se\u2010PEG). The ROS\u2010responsive shell keeps the platform inert systemically and confines its activity to irradiated tumors, achieving spatiotemporal control. Upon RT activation, the released SDT core utilizes the anaerobic characteristics of the tumor microenvironment to specifically construct nanowire connections with tumor cells, thereby establishing the electronic synapse for current delivery. Simultaneously, the Pd\/Pt bio\u2010alloy enhances\n                    <jats:italic>Shewanella<\/jats:italic>\n                    's lactate metabolism and electron transfer. This enhancement enables the platform to generate a continuous bioelectric current fueled by tumor lactate. RT also induces the Pd\/Pt bio\u2010alloy to release high\u2010energy electrons, which are then delivered to the tumor cells alongside the amplified bioelectric current through the nanowire. This dual\u2010pathway electron delivery enhances tumor cell ablation and yields prominent inhibition of primary tumor growth. The treatment also induces systemic antitumor effects, as the release of tumor antigens from electro\u2010ablation and bacterial antigens from RT\u2010mediated bacterial disruption triggeres local immune activation and an abscopal effect. Moreover, the combination with anti\u2010PD\u20101 treatment further enhances these effects, resulting in nearly complete tumor eradication and durable tumor control. This work demonstrates a bioelectronic therapy that integrates tumor metabolic intervention with systemic immune activation for the treatment of immunologically cold solid tumors.\n                  <\/jats:p>","DOI":"10.1002\/adma.74300","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:00:21Z","timestamp":1785308421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomineralized\n                    <i>Shewanella<\/i>\n                    Exploits\u00a0Tumor Lactate Metabolism via Biological Nanowires for Radiotherapy\u2010Synergized Bioelectric Ablation and Systemic Immunity"],"prefix":"10.1002","volume":"38","author":[{"given":"Mengen","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Second Xiangya Hospital of Central South University  Changsha Hunan China"},{"name":"Hunan Provincial Engineering Research Centre of Translational 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