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Here, we report the de novo design of a spiky pollen\u2010based vanadium artificial enzyme particle (VAE\u2010Pollen) that integrates potent reactive oxygen species (ROS)\u2010catalytic activity with immune priming to prevent both primary and secondary bacterial infections. Experimental and theoretical analyses confirm that bacteria are efficiently captured by the micro\u2010structured surface of VAE\u2010Pollen, and the introduction of oxygen vacancies modulates the electronic configuration of vanadium catalytic sites, significantly enhancing their versatile ROS\u2010catalytic performance. Meanwhile, VAE\u2010Pollen enhances bacterial capture and ROS\u2010triggered release of bacterial antigens, which mimics the sustained allergen exposure characteristic of natural pollen, thereby potently activating systemic defensive responses and providing sustained anti\u2010infective surveillance to prevent secondary wound infection. Notably, the VAE\u2010Pollen demonstrates significant efficacy in treating methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>MRSA<\/jats:italic>\n                    ) and preventing its recurrence, offering a potent and intelligent antibacterial alternative that may circumvent the limitations of conventional antibiotics.\n                  <\/jats:p>","DOI":"10.1002\/adma.74304","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:38:26Z","timestamp":1785015506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pollen\u2010Based Artificial Enzyme With Efficient Biocatalysis and Immune\u2010Priming to Prevent Primary and Secondary Wound Infection"],"prefix":"10.1002","volume":"38","author":[{"given":"Jiangge","family":"Li","sequence":"first","affiliation":[{"name":"College 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