{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:06:01Z","timestamp":1789988761273,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Impaired neurovascular\u2013immune coupling severely hampers chronic wound healing. Although the transient receptor potential vanilloid 1 (TRPV1) channel represents a promising therapeutic target, its therapeutic application remains limited by imprecise activation. Here, we developed a three\u2010stage adaptive and heat\u2010absorbing hydrogel (termed HMCG) that enables programmable and localized TRPV1 activation under near\u2010infrared (NIR) irradiation. HMCG forms reversible boronate ester bonds between PVA and TSPBA, enabling a sol\u2013aerosol\u2013gel adaptive with sprayable handling, self\u2010adaptation, and conformal coverage of complex wound topologies. This dynamic behavior ensures close biointerface contact and controlled thermal regulation during stimulation. Embedded Ca\u2010gallic acid metal\u2013organic frameworks (MOFs) act as photon\u2010thermal converters, where ligand\u2010metal charge transfer and \u03c0\u2013\u03c0 stacking drive rapid nonradiative relaxation, leading to efficient and controllable heat absorption. Brief NIR exposure triggers the sustained release of capsaicin and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , elevating the local temperature to 43\u00b0C, within the TRPV1 activation window and with a reduced risk of nonspecific thermal overstimulation. Together, the tri\u2010stage adaptive design helps buffer heat, maintains topological adaptability, and synchronizes mild photothermal and biochemical cues. This controlled light\u2010heat\u2010chemical coupling supports the restoration of neurovascular\u2013immune coupling and promotes tissue regeneration in diabetic skin lesion models, establishing a controlled, programmable platform for TRPV1\u2010targeted regenerative therapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.74307","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:25:31Z","timestamp":1785014731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TRPV1 Activation via a Three\u2010Stage Adaptive Heat\u2010Absorbing Hydrogel Drives Neurovascular\u2013Immune Coupling"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7864-0601","authenticated-orcid":false,"given":"Hu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics General Hospital of Southern Theater Command Southern Medical University Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglei","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics General Hospital of Southern Theater Command Southern Medical University Guangzhou Guangdong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9244-0454","authenticated-orcid":false,"given":"Yaping","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P. R. 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