{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:05:18Z","timestamp":1789988718952,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001381","name":"National Research Foundation Singapore","doi-asserted-by":"publisher","award":["NRF\u2010CRP26\u20102021\u20100002"],"award-info":[{"award-number":["NRF\u2010CRP26\u20102021\u20100002"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>PANoptosis has emerged as a compelling strategy to potentiate antitumor immune responses. However, achieving specific PANoptotic cancer\u2010cell death while sparing normal tissues remains a central challenge, as current strategies are constrained by inadequate spatiotemporal controllability and insufficient generation of key effector species, particularly reactive oxygen species (ROS). In this study, we report a class of PANoptosis nanoinducer constructed from atomically dispersed high\u2010entropy metal sites, enabling spatiotemporally controlled near\u2010infrared (NIR)\u2010amplified cancer immunotherapy. The unique high\u2010entropy metal\u2010site configuration of the resulting nanozymes (HENA@PEG) boosts catalytic efficiency through atomic\u2010level synergism, while enabling precise, pH\u2010gated control over ROS generation via catalytic activation. In addition, nanozyme\u2010mediated photothermal therapy (PTT) not only induces direct tumor ablation but also supplies exogenous thermal energy to accelerate the catalytic reactions. The co\u2010programmed integration of endogenous and exogenous activations confers tumor\u2010site\u2010adaptive biocatalysis, thereby enabling precise spatiotemporal induction of PANoptosis. Both in vitro and in vivo investigations reveal that the resulting nanoinducer effectively promotes dendritic cell maturation and cytotoxic T\u2010cell activation, ultimately amplifying antitumor immune responses and markedly suppressing 4T1 tumor progression. Overall, this work establishes a high\u2010entropy\u2010engineered nanoinducer that overcomes the limitations of nonspecific PANoptosis and immune evasion, representing a promising avenue toward more efficient and precisely targeted cancer immunotherapy.<\/jats:p>","DOI":"10.1002\/adma.74319","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:27:01Z","timestamp":1785238021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Entropy\u2010Engineered Nanoinducer for Spatiotemporally Programmed PANoptosis and NIR\u2010Amplified Cancer Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-7092","authenticated-orcid":false,"given":"Yue","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University  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