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Here, we report a bioelectronic sensor based on an organic electrochemical transistor (OECT) driven by a laser\u2010induced graphene (LIG) array. By integrating an alternating\u2010current (AC)\u2010mediated LIG rapid incubation system (LRIS), the platform enables multiplexed protein profiling directly from clinical samples within approximately 6\u00a0min, with attomolar\u2010level detection limits. We identify the glycoprotein non\u2010metastatic melanoma protein B (GPNMB)\/granulin (GRN) ratio as a sensitive composite biomarker of neuroinflammatory dysregulation, showing pronounced alterations at early disease stages and complementing \u03b1\u2010synuclein for PD assessment. In PD mouse models spanning mild to severe stages (\n                    <jats:italic>n<\/jats:italic>\n                    = 32), this ratio correlated with disease progression and enabled the detection of mild neuronal loss. Clinical validation in healthy individuals and patients with PD or prodromal PD (\n                    <jats:italic>n<\/jats:italic>\n                    = 54) showed that the GPNMB\/GRN ratio distinguished patients with PD from healthy controls with 80% sensitivity, 90% specificity, and 85% accuracy. Incorporating \u03b1\u2010synuclein further improved diagnostic accuracy. This biomarker\u2013platform strategy provides a rapid, ultrasensitive, and scalable framework for blood\u2010based PD screening and early risk assessment.\n                  <\/jats:p>","DOI":"10.1002\/adma.74326","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:28:50Z","timestamp":1785241730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Hematological Profiling of the GPNMB\/GRN Ratio via Bioelectronic Platform for Early Diagnosis of Parkinson's Disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Xiaohong","family":"Jiang","sequence":"first","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology (GTIIT)  Shantou China"},{"name":"Faculty of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology (IIT)  Haifa 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Laboratory of Clinical Laboratory Diagnostics (Ministry of Education) College of Laboratory Medicine Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minchao","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Shantou University Medical College  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Liang","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology (GTIIT)  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runzhi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology (GTIIT)  Shantou China"},{"name":"Faculty of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology (IIT)  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilai","family":"Fu","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology (GTIIT)  Shantou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Yan","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Guangdong Technion\u2010Israel Institute of Technology (GTIIT)  Shantou China"},{"name":"Faculty of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology (IIT)  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2247-3952","authenticated-orcid":false,"given":"Hong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Biology &amp; Guangdong Provincial Key Laboratory of Marine Biotechnology College of Science Shantou University  Shantou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Segal","sequence":"additional","affiliation":[{"name":"Faculty of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology (IIT)  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4386-0740","authenticated-orcid":false,"given":"Cheng","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Medicine The Chinese University of Hong Kong  Shenzhen China"},{"name":"Guangdong Basic Research Center of Excellence for Aggregate Science School of Science and Engineering The Chinese University of Hong Kong  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-1512","authenticated-orcid":false,"given":"Sahika","family":"Inal","sequence":"additional","affiliation":[{"name":"Organic Bioelectronics Laboratory 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